Tujuan Umum. Tujuan Khusus.

ABSTRAK Latar Belakang: Melanoma maligna merupakan bentuk kanker kulit yang paling berbahaya. Insiden dan mortalitas melanoma maligna meningkat di seluruh dunia. Mortalitas melanoma maligna berhubungan dengan faktor prognosis. Tumor infiltrating lymphocytes TILs, mitotic index, dan metastasis termasuk dari faktor prognosis melanoma maligna. Tujuan penelitian: Tujuan penelitian ini adalah untuk melihat distribusi frekuensi TILs dan nilai mitotic index pada melanoma maligna. Metode Penelitian: Penelitian ini merupakan penelitian serial kasus yang melibatkan 13 sampel. Data merupakan data sekunder yang diperoleh dari instalasi rekam medik dan instalasi patologi anatomi Rumah Sakit Umum Pusat Haji Adam Malik tahun 2011-2015. Hasil: Berdasarkan data yang diperoleh, terdapat delapan orang 61,5 sampel yang mengalami metastasis. TILs present berjumlah delapan orang 61,5 dan TILs absent berjumlah lima orang 38,5. Jumlah sampel nilai mitotic index ≥1mm 2 adalah Sembilan orang 69,2 dan nilai mitotic index 1mm 2 adalah empat orang 30,8. Kata kunci : melanoma maligna, tumor-infiltrating lymphocytes, mitotic index ABSTRACT Background: Malignant melanoma is the most dangerous type of skin cancer. There has been a sharp increase in the global incidence and mortality of malignant melanoma. Recent studies have shown that mortality in patients with malignant melanoma is associated with prognostic factors. This study examined tumor infiltrating lymphocytes TILs, mitotic index and metastases are prognostic factors of malignant melanoma. Purpose: The aim of this study was to determine the frequency distribution of TILs and mitotic index point in malignant melanoma. Methods: This was a case-series study with secondary data analysis. All data were obtained through patient’s medical record in RSUP Haji Adam Malik in 2011-2015. During this period, 13 of them were selected as samples. Result: This study demonstrated that eight patients 61.5 were found to have metastases cases. From the total sample of 13 patients, eight patients 61.5 had TILs present, and five patients 38.5 had TILs absent. Nine patients 69.2 were examined having mitotic index ≥1mm 2 and four patients 30.8 had mitotic index 1mm 2 . Keyword : malignant melanoma, tumor infiltrating lymphocytes, mitotic index