S. Levitt, B.A. - MDPhD student

68 SCIENTIFIC SESSIONS September 9-12 | ------------------------------------------------------------------------ 046 M Symposium Mycology 2012: Top Papers Sunday, 4:00 p.m.– 6:00 p.m. . . . . . . . . . . . . . . . . . . . . Room 132 UAN: 0391-9999-12-050-L04-P Convener: Dimitrios P. Kontoyiannis, MD - Frances King Black Endowed Professor Univ. of Texas MD Anderson Cancer Ctr., Houston, TX. Experts: 456 Thomas F. Patterson, MD - Professor and Chief, Infectious Disease Univ. of Texas Hlth. Sci. Ctr., San Antonio, TX. 457 David Denning, MD - Professor Univ. Hosp. of South Manchester, Manchester, United Kingdom. Objectives: Upon completion of this Symposium Session, the participant should be able to: Analyze major findings in fungal diseases; Understand new insights into the diagnosis and management of invasive fungal infections; and Identify epidemiology features and understand pathogenesis of invasive fungal infections. Intended Audience: Clinicians, trainees, mycologists and researchers. Level: Advanced ------------------------------------------------------------------------ 047 C1 Slide Session StructureFunction Sunday, 4:00 p.m.–6:30 p.m. . . . . . . . Esplanade Ballroom 300 UAN: 0391-9999-12-051-L04-P Moderators: Timothy G. Palzkill, PhD - Professor Baylor Coll. of Med., Houston, TX. Laurent Poirel, PhD - Senior Scientist Hop. de Bicetre, Le Kremlin Bicetre, France. Objectives: Upon the completion of this Slide Session, the participant should be able to: Identify molecular mechanisms of resistance; Discuss the general properties that govern the relationship between anti- biotic and resistance proteins; and Discuss the correlation of 3D structure with mechanistic activity of resis- tance protien. Presentations: 4:00 p.m. C1-458 Structural and Functional Characterization of Aminoglycoside N-Acetyltransferases AAC6’-Ig and -Ih from Acinetobacter spp

P. J. Stogios, PhD - Research Scientist

1,2 , D. Meziane-Cherif, PhD - Research Scientist 3 , E. Evdokimova, MSc - Research Technician 1,2 , A. Savchenko, PhD - Professor 1,2 , P. Courvalin, MD, FRCP - Professor 3 ; 1 Univ. of Toronto, To- ronto, Canada, 2 Ctr. for Structural Genomics of Infectious Diseases, Toronto, Canada, 3 Inst. Pasteur, Paris, France. 4:15 p.m. C1-459 Crystal Structure of the Class A Beta-Lactamase from Bacil- lus licheniformis BS3 Inhibited by Tazobactam

P. Power, PhD - Researcher

1 , P. Mercuri, PhD - Researcher 2 , R. Herman, BSc - Research Assistant 2 , F. Kerff, PhD - Researcher 2 , G. Gutkind, PhD - Researcher 1 , M. Galleni, PhD - Researcher 2 , P. Charlier, PhD - Researcher 2 , E. Sauvage, PhD - Researcher 2 ; 1 Univ. of Buenos Aires, Buenos Aires, Argen- tina, 2 Univ. of Liege, Liege, Belgium. 4:30 p.m. C1-460 Crystal Structures of the Pen ơ-Lactamases of Burkholderia cepacia Bc and Burkholderia pseudomallei Bp

K. M. Papp-Wallace, PhD - Research Scientist and Instructor

1 , R. A. Bonomo, MD - Professor 1 , N. Ohuchi, PhD - Research Associate 2 , M. Nu- kaga, PhD - Associate Professor 2 ; 1 Cleveland VAMC and CWRU, Cleveland, OH, 2 Josai Intl. Univ., Togane City, Chiba, Japan. 4:45 p.m. C1-461 Evolutionary Mechanisms for Metallo-Beta-Lactamases M. R. Meini, BS - PhD, M. M. Gonzalez, BS - PhD, P. E. Tomatis, PhD - Research Assistant, A. J. Vila, ScD - Professor; IBR, Rosario, Argentina. 5:00 p.m. C1-462 Structural and Biochemical Characterization of Substrate Specificity Determining Residues in CTX-M-14 A. Cardenas, BS - Graduate Student, N. G. Brown, PhD - Research Associate, L. B. Horton, PhD - Research Associate, T. G. Palzkill, PhD - Professor; Baylor Coll. of Med., Houston, TX. 5:15 p.m. C1-463 Unraveling a Final Common Pathway: The K234R Sub- stitution in SHV Mediates AmoxicillinClavulanic Acid AC Resistance

M. L. Winkler, BA - Student

1 , E. Rodkey, BS - Student 1 , M. Taracila, MS - Research Assistant 1 , C. R. Bethel, MS - Research Assistant 2 , S. M. Drawz, PhD - Student 1 , K. Papp-Wallace, PhD - Investigator 2 , F. van den Akker, PhD - Professor 1 , R. A. Bonomo, MD - Professor 3 ; 1 CWRU, Cleveland, OH, 2 VAMC, Cleveland, OH, 3 CWRU, VAMC, Cleveland, OH. 5:30 p.m. C1-464 Defining the Role of D179 in the Substrate Profile of KPC-2 ơ-Lactamase

P. S. Levitt, B.A. - MDPhD student

1 , K. M. Papp-Wallace, PhD - Instructor 1,2 , R. A. Bonomo, MD - Professor 3 ; 1 CWRU, Cleveland, OH, 2 Cleveland VAMC, Cleveland, OH, 3 VAMC, Cleveland, OH. 5:45 p.m. C1-465 The Crystal Structure of the DIM-1 Metallo-Beta-Lacta- mase from Pseudomonas stutzeri M. P. S. Booth, PhD - Research Assistant 1 , L. Poirel, PhD - Associate Re- searcher 2 , P. Nordmann, MD, PhD - Professor 2 , J. Spencer, PhD - Lecturer 1 ; 1 Univ. of Bristol, Bristol, United Kingdom, 2 Hosp. de Bicêtre, Paris, France. 6:00 p.m. C1-466 INQ-1: Preliminary Characterization of a ơ-Lactamase from Inquilinus limosus M. Pino, Lic. - Reseacher, P. Power, PhD - Reseacher, J. Di Conza, PhD - Professor, M. Ruggiero, Lic. - Researcher, G. Gutkind, PhD - Professor; Fac. Farm. y Bioq., UBA, Buenos Aires, Argentina. 69 SUNDAY SCIENTIFIC SESSIONS Final Program 6:15 p.m. C1-467 Substrate Specificity in Class D ơ-Lactamases: A Structure Based Comparison of OXA-1 and OXA-24 with Oxacillin Bound C. M. June, MS - Research Assistant 1 , B. C. Vallier, undergraduate - Student 1 , R. A. Bonomo, MD - Professor 2 , D. A. Leonard, PhD - Professor 1 , R. A. Powers, PhD - Professor 1 ; 1 Grand Valley State Univ., Allendale, MI, 2 Cleve- land VAMC, Cleveland, OH. ------------------------------------------------------------------------ 048 K Slide Session Difficulties of Clostridium difficile Sunday, 4:00 p.m.–6:30 p.m. . . . . . . . . . . . . . . . . . . . . Room 254 UAN: 0391-9999-12-052-L04-P Moderator: Dale N. Gerding, MD Edward Hines Jr. VA Hosp., Hines, IL. Objectives: Upon the completion of this Slide Session, the participant should be able to: Describe current epidemiology of Clostridium difficile stain type C; Identify factors associated with outcome of C. difficile infection; and Discuss clinical and economic consequences of vancomycin and fidaxomi- cin in the treatment of C. difficile infection. Presentations: 4:00 p.m. State-of-the-Art Minilecture 468 Update on C.difficile Infection Dale N. Gerding, MD Edward Hines Jr. VA Hosp., Hines, IL. 4:30 p.m. K-469 Clostridium difficile Strain Types from United States Hospitals

F. C. Tenover, PhD - Executive Director