Richaud Chen McKenney Rutgersson

89 MONDAY SCIENTIFIC SESSIONS Final Program ------------------------------------------------------------------------ 084 B Poster Session Antimicrobial Therapy in Animal Models I Monday, 11:15 a.m.–1:15 p.m. . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: B-645 Comparison of Six Generics Vancomycin VAN Products from Europe and America in the Treatment of Methicillin-Resistant Staphylococcus aureus MRSA Experimental Endocarditis in Rabbits P. Tattevin 1 , A. Saleh-Mghir 2 , B. Davido 2 , I. Ghout 3 , L. Massias 4 , C. Garcia de la Maria 5 , C. Muller-Serieys 4 , J. M. Miro 5 , B. A. Diep 6 , A. Cré- mieux 2 ; 1 Pontchaillou Univ. Hosp., Rennes, France, 2 Raymond Poincaré Univ. Hosp., Garches, France, 3 Ambroise Paré Univ. Hosp., Boulogne, France, 4 Bichat Univ. Hosp., Paris, France, 5 Univ. Hosp. Clinic-IDIBAPS, Barcelona, Spain, 6 SFGH, Univ. of California, San Francisco, CA. B-646 Relationship Between In Vitro Vancomycin Susceptibility in Biofilms and Treatment Outcomes in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus W. Abdel Hady 1 , A. S. Bayer 1,2 , K. Seidl 1,3 , C. C. Nast 2,4 , A. R. Horswill 5 , Y. Q. Xiong 1 ; 1 LABioMed at Harbor-UCLA Med. Ctr., Torrance, CA, 2 David Geffen Sch. of Med. at UCLA, Los Angeles, CA, 3 Univ. of Zurich, Zurich, Switzerland, 4 Cedars-Sinai Med. Ctr., Los Angeles, CA, 5 Univ. of Iowa, Iowa City, IA. B-647 Efficacy of the Combinations of Fosfomycin with Daptomycin or Rifampin in an Experimental Foreign-Body Infection FBI by Methicillin-Resistant Staphylococcus aureus MRSA C. Garrigós, O. Murillo, J. Lora-Tamayo, M. Vivas, F. Tubau, Dr , J. Cabo, Dr , C. Cabellos, Dr , J. Ariza, Dr ; Hosp. Bellvitge, Barcelona, Spain. B-648 Effectiveness of Cloxacillin CLO Plus Vancomycin VAN Compared to CLO, VAN, and Daptomycin DAP in the Treat- ment of Methicillin-Resistant MRSA or Methicillin-Suscep- tible MSSA Staphylococcus aureus in a Rabbit Model of Experi- mental Endocarditis EE X. Castañeda, C. García-de-la-Maria, A. del-Rio, D. Soy, Y. Armero, C. Cervera, A. Moreno, J. M. Pericas, M. Almela, C. A. Mestres, C. Falces, S. Ninot, J. M. Gatell, F. Marco, J. M. Miro, Hospital Clinic Endocarditis Study Group; Hosp. Clinic - IDIBAPS, Barcelona, Spain. B-649 Addition of Daptomycin D to Levofloxacin LVX Increased the Efficacy of Levofloxacin Monotherapy against a Methicillin- Sensitive S. aureus MSSA Strain in Experimental Meningitis and Prevented Development of Levofloxacin-Induced Resistance

P. Cottagnoud

1 , M. Cottagnoud 2 , F. Acosta 2 , A. Bizzini 3 , S. Leib, 4 ; 1 Klinik Sonnenhof, Bern, Switzerland, 2 Spitalnetzbern Ziegler, Bern, Switzerland, 3 CHUV, Lausanne, Switzerland, 4 Inst. für Infektionskrankheiten, Bern, Switzerland. B-650 Inter-Laboratory Comparison of Treatment Response in a Murine Model of Methicillin Resistant Staphylococcus aureus MRSA Bacteremia

L. K. Najvar

1,2 , A. Ibrahim 3 , N. P. Wiederhold 4,1 , G. Luo 3 , R. A. Bocanegra 1,2 , T. Ghebremariam 3 , W. R. Kirkpatrick 1,2 , S. G. Filler 3 , T. F. Patterson 1,2 ; 1 UTHSCSA, San Antonio, TX, 2 STVHCS, San Antonio, TX, 3 Harbor- UCLA, Torrance, CA, 4 UT Austin, Austin, TX. B-651 Linezolid LZD Prevents the Development of Lung Damages in a Murine Model of Methicillin-Resistant Staphylococcus aureus MRSA Pneumonia PN C. Jacqueline, A. Broquet, A. Roquilly, M. Davieau, G. Potel, J. Caillon, K. Asehnoune; UPRES EA 3826, Nantes, France. B-652 Comparative Activities of Vancomycin, Tigecycline and Ri- fampin Alone and in Combination in a Rat Model of Methicillin- Resistant Staphylococcus aureus MRSA Foreign Body Osteomyelitis P. Vergidis, S. S. Schmidt, J. N. Mandrekar , J. M. Steckelberg, R. Patel; Mayo Clinic, Rochester, MN. B-653 Experimental Assessment of Calcium-Deficient Apatite Delivering Daptomycin in Acute Osteomyelitis: A New Effective Approach?

G. Amador

1 , H. Gautier 2 , C. Desessard 1 , V. Le Mabecque 1 , A. Miegeville 1 , J. Bouler 2 , P. Weiss, DDS 2 , G. Potel 1 , J. Caillon 1 , C. Jacqueline 1 ; 1 EA3826, Med. Sch., Nantes, France, 2 INSERM U791, Nantes, France. B-654 Comparison of Linezolid and Daptomycin in an Experimen- tal Murine Model of VRE Faecium Bacteremia: Emergence of Daptomycin-Nonsusceptibility During Daptomycin Treatment Y. Q. Xiong, W. Abdel Hardy, S. J. Eells, A. S. Bayer, J. A. McKinnell; LA Biomed Res. Inst., Torrance, CA. B-655 Murine Model of Acute Vancomycin-Resistant Enterococcal VRE Bacteremia Y. Q. Xiong, W. Abdel Hardy, S. J. Eells, A. S. Bayer, J. A. McKinnell; LA Biomed Res. Inst., Torrance, CA. B-656 In Vivo Antibacterial Activity of Alpha-Melanocyte Stimulat- ing Hormone against Staphylococcus aureus Withdrawn B-657 Effects of Dagibatran on a Murine Model of Staphylococcus aureus Hematogenous Pulmonary Infection Y. Morinaga, K. Yanagihara, N. Kaku, Y. Migiyama, Y. Harada, K. Nagaoka, K. Yamada, K. Izumikawa, H. Kakeya, Y. Yamamoto, S. Kohno; Nagasaki Univ., Nagasaki, Japan. B-658 Experimental Study of the Efficacy of High Dose of Dapto- mycin in the Therapy of Cephalosporin-Resistant Pneumococcal Meningitis M. Vivas, E. Force, C. Garrigós, F. Tubau, J. Liñares, I. Pelegrín, J. Ariza, C. Cabellos; Hosp. de Bellvitge, Hosp. del Llobregat, Spain. B-659 Synergism Between the Combination of Cpl-1 with Daptomy- cin or Vancomycin against Streptococcus pneumoniae in Mice with Bacteremia J. Vouillamoz 1 , P. Moreillon 1 , M. Giddey 1 , V. A. Fischetti 2 , G. Resch 1 ; 1 Univ. of Lausanne, Lausanne, Switzerland, 2 The Rockefeller Univ., New York, NY. B-660 Impact of Reduced Susceptibility to Daptomycin in E. faecium on the Activity of This Antibiotic In Vitro and In Vivo

C. Richaud

1 , F. Chau 1 , M. Sotier 2 , A. Bleibtreu 3 , B. Fantin 1 , V. Cattoir 4 , A. Lefort 1 ; 1 EA 3964, Univ. Paris Diderot, Paris, France, 2 Lab de Toxicologie et Pharmacocinétique, Bichat Hosp., Paris, France, 3 UMR 722, Univ. Paris Diderot, Paris, France, 4 EA 4655, Univ. Caen Côte de Nacre, Caen, France. B-661 Prostaglandins Alter the Innate Immune Response to Group A Streptococcus Infection Withdrawn 90 SCIENTIFIC SESSIONS September 9-12 | B-662 In Vitro Activity of Cadazolid ACT-179811 against Clostridi- um difficile and in an In Vitro Gut Model of C. difficile infection S. Baines, G. Crowther, S. Todhunter, J. Freeman, M. Wilcox; Leeds Teach- ing Hosp. Univ. of Leeds, Leeds, United Kingdom. B-663 Effects of Vancomycin and Huo Xiang Zheng Qi Liquid on Clostridium difficile Infection in C57BL Mice

M. Chen

1,2 , L. Zhai 1 , K. Schonning 3 , L. P. Andersen 1 , W. A. Alpizar 4 , O. D. Laerum 4 , A. Friis-Moeller 3 ; 1 Rigshospitalet, Copenhagen,, Denmark, 2 Sonderjylland Hosp., Aabenraa, Denmark, 3 Univ. Hosp. Hvidovre, Copen- hagen,, Denmark, 4 The Finsen Ctr., Copenhagen,, Denmark. B-664 Efficacy Comparison between LFF571 and Fidaxomicin in the Hamster Model of Clostridium difficile Infection

D. McKenney

1 , A. Williams 2 , M. LaMarche 2 , J. Praestgaard 3 , J. Leeds 1 ; 1 Novartis Inst.s for BioMed. Res., Emeryville, CA, 2 Novartis Inst. for BioMed. Res., Cambridge, MA, 3 Novartis, East Hanover, NJ. ------------------------------------------------------------------------ 085 C1 Poster Session Genetics and Resistance Monday, 11:15 a.m.–1:15 p.m. . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: C1-665 High Levels of Mobile Quinolone Resistance Genes Found Near a Waste Water Treatment Plant Serving Antibiotic Manu- facturers

C. Rutgersson

1 , C. Flach 1 , N. Marathe 1,2 , E. Kristiansson 3 , A. Janzon 1 , J. Fick 4 , Y. Shouche 2 , E. Moore 5 , D. G. J. Larsson 1 ; 1 Inst. for Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg Univ., Gothenburg, Sweden, 2 Natl. Ctr. for Cell Sci., Pune Univ., Pune, India, 3 Chalmers Univ. of Tech., Gothenburg, Sweden, 4 Umeå Univ., Umeå, Sweden, 5 The Sahlgrenska Univ. Hosp. Univ. of Gothenburg, Gothenburg, Sweden. C1-666 Regulation of Class 1 Integron Integrase Expression in Biofilm

E. Strugeon