Yin D. Buynak icaac 2012 finalprogram web4a

100 SCIENTIFIC SESSIONS September 9-12 | F-842 Comparative Efficacy of BAL30072, Aztreonam, Meropenem and Ceftazidime and Effects of Dose Fractionation in a Murine Thigh Infection Model J. K. Gould 1 , A. Sattar 1 , G. M. Daws 1 , L. J. Payne 1 , J. Spikermann 2 , W. Stubbings 2 , A. Schmitt-Hoffmann 2 , M. G. P. Page 2 , P. A. Warn 1 ; 1 Euprotec Ltd. Manchester, United Kingdom, 2 Basilea Pharmaceutica Intl. Ltd. Basel, Switzerland. F-843 Broad Spectrum Cephalosporins with Urea-Substituted Pyridinium Group at the C-3’ Position Exhibiting Potent Activity against Methicillin-Resistant Staphylococcus aureus and Pseudomo- nas aeruginosa Y. He, N. Yin, J. Romero, C. Abel, R. Busch, B. Wang, A. Pearson, P. Herradura, D. Keith, J. Rock, L. Chesnel, K. Cassidy C. Monahan, S. Zhang, J. Silverman, D. Alexander, C. Metcalf Y. Gu; Cubist Pharmaceuticals, Lexington, MA. F-844 Synthesis and Structure-Activity Relationships of Aminoalkyl- N’-Pyridin-4-yl Benzohydrazide-Derived Cephalosporins with Broad Spectrum Activity against Methicillin-Resistant Staphylo- coccus aureus and Pseudomonas aeruginosa J. Romero, Y. He, N. Yin, C. Abel, R. Busch, B. Wang, A. Pearson, P. Her- radura, F. Epie, D. Keith, J. Rock, L. Chesnel, K. Cassidy, C. Monahan, S. Zhang, J. Silverman, D. Alexander, C. Metcalf-, Y. Gu; Cubist Pharmaceuti- cals, Lexington, MA. F-845 Structure-Activity Relationship Studies of Novel Cephalo- sporins with Substituted Pyrazolium Groups at the C-3’ Position against Methicillin-Resistant Staphylococcus aureus and Pseudomo- nas aeruginosa

N. Yin

1 , Y. He 1 , J. Romero 1 , C. Abel 1 , R. Busch 1 , B. Wang 1 , A. Pearson 2 , P. Herradura 3 , F. Epie 1 , D. Keith 1 , J. Rock 1 , L. Chesnel 1 , K. Cassidy 1 , C. Monahan 1 , Y. Li 1 , C. Chuong 1 , S. Zhang 1 , J. Silverman 1 , D. Alexander 1 , C. Metcalf 1 , Y. Gu 1 ; 1 Cubist Pharmaceuticals, Lexington, MA, 2 Biotech Generics LLC, Brooklyn, NY, 3 Genentech, San Francisco, CA. F-846 In Vivo Efficacy of CB-027 against Methicillin-Resistant Staphylococcus aureus, and Ceftazidime-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Infections in Mice S. Zhang, L. I. Mortin, Y. Li, C. Chuong, H. Corkrey, C. Khang, A. Alsup, T. Li, A. Arya, Y. He, N. Yin, J. Rock, C. Abel, Y. Gu, D. Alexander, C. Metcalf, J. Silverman, C. Murphy; Cubist Pharmaceuticals, Lexington, MA. F-847 Versatile 6 ơ-hydroxymethyl Penicillanic Acid Sulfone 6 ơ-HM-sulfone Derivatives asơ-Lactamase Inhibitors

J. D. Buynak

1 , M. Nottingham 1 , C. Bethel 2 , K. Papp-Wallace 2 , D. McLeod 1 , S. R. R. Pagadala 1 , M. Winkler 3 , R. A. Bonomo 2 ; 1 SMU, Dallas, TX, 2 VAMC, Cleveland, OH, 3 CWRU, Cleveland, OH. F-848 Discovery of RPX7009, a Broad-Spectrum Beta-Lactamase Inhibitor with Utility vs. Class A Serine Carbapenemases

S. J. Hecker