Ghannoum, PhD - Professor

113 MONDAY SCIENTIFIC SESSIONS Final Program Presentations: 1:30 p.m. M-1055 Cx3cr1 is Important for Host Defense against Invasive Candidiasis IC in Mice and Humans

M. S. Lionakis, MD - Assistant Clinical Investigator

1 , M. Swamydas, PhD - Research Associate 1 , B. G. Fischer, BS - Student 1 , T. Plantinga, PhD - Postdoc 2 , M. Jaeger, BS - Student 2 , M. D. Johnson, PharmD - Assistant Professor 3 , J. R. Perfect, MD - Professor 3 , B. D. Alexander, MD - Associate Professor 3 , B. Kullberg, MD - Professor 2 , M. Netea, MD - Professor 2 , P. M. Murphy, MD - Chief 1 ; 1 NIH, Bethesda, MD, 2 Radboud Univ., Nijmegen, Netherlands, 3 Duke, Durham, NC. 1:45 p.m. M-1056 Nanostring Analysis of Candida albicans Gene Expression During Intra-Abdominal Candidiasis IAC Provides Insights into Pathogenesis and Reveals Rewiring of Regulatory Pathways S. Cheng, MD - Research Associate Professor 1 , C. Clancy, MD - Associ- ate Professor 1 , A. P. Mitchell, PhD - Professor 2 , W. Xu, PhD - Fellow 1 , S. Fanning, PhD - Fellow 2 , N. Solis, MS - Research Associate 3 , S. Filler, MD - Professor 3 , M. Nguyen, MD - Professor 1 ; 1 Univ. of Pittsburgh, Pittsburgh, PA, 2 Carnegie Mellon Univ., Pittsburgh, PA, 3 UCLA, Los Angeles, CA. 2:00 p.m. M-1057 Conditional Expression of Cell Wall Polysaccharide-Encod- ing Genes in C. albicans and A. fumigatus Reproduces Immunophar- macologic Effects of Caspofungin and Nikkomycin Z Exposure

R. E. Lewis, Pharm.D. - Professor

1 , G. Liao, PhD - Research Assistant 1 , K. Young, MS - Researcher 2 , C. M. Douglas, PhD - Researcher 2 , D. P. Kon- toyiannis, M.D. - Professor 3 ; 1 Univ. of Houston Coll. of Pharmacy, Houston, TX, 2 Merck Co, Kenilworth, NJ, 3 The Univ. of Texas M.D. Anderson Cancer Ctr., Houston, TX. 2:15 p.m. M-1058 Anidulafungin ANF Compared to Caspofungin CAS in a Non-Neutropenic Mouse Model of Invasive Candidiasis IC Caused by ANF-Susceptible S C. parapsilosis C.p Isolates with Different Degrees of In Vitro Non-Susceptibility NS to CAS: MIC Does Not Tell the Whole Story

D. Dimopoulou, MD - Research Fellow

1 , G. Hamilos, MD - Attending Physician 1 , G. Samonis, MD - Professor 1 , D. P. Kontoyiannis, MD, ScD, FACP - Professor 2 ; 1 Univ. Hosp. of Heraklion, Heraklion,Crete, Greece, 2 The Univ. of Texas MD Anderson Cancer Ctr., Houston, TX. 2:30 p.m. M-1059 Candida glabrata Heteroresistance to Fluconazole is Associ- ated with Aneuploidy and Chromosomal Translocations Involving the PDH1 Gene

O. Zimmerman, MD- Physician

1 , A. Novikov, BSc - Research Assistant 1 , T. Finn, MD- Physician 1 , Y. Paran, MD- Physician 1 , N. Osherov, PhD - Researcher 2 , R. Ben-Ami, MD- Physician 1 ; 1 Tel Aviv Sourasky Med. Ctr., Tel Aviv, Israel, 2 Tel Aviv Univ., Tel Aviv, Israel. 2:45 p.m. M-1060 Breath Volatile Organic Compound VOC Profiles for the Diagnosis of Invasive Aspergillosis IA

S. Koo, MD - Physician

1,2 , H. R. Thomas, AB - Res Asst 1 , P. Rearden, PhD - Staff 3 , J. Comolli, PhD - Staff 3 , L. R. Baden, MD - Physician 1,2 , F. M. Marty, MD - Physician 1,2 ; 1 Brigham and Women’s Hosp., Boston, MA, 2 Harvard Med. Sch., Boston, MA, 3 Draper Lab., Cambridge, MA. 3:00 p.m. M-1061 A Non-Echinocandin Compound Isolated from a Marine Sponge Mediates its Antifungal Activity by Targeting the Fungal Cell Wall S. Tripathi, PhD - Postdoctoral Associate, T. Xu, PhD - Postdoctoral As- sociate, Q. Feng, MS - Senior R D Biologist, M. Jacob, PhD - Research Scientist, W. Xu, PhD - Postdoctoral Associate, X. Li, PhD - Senior Scien- tist, A. Clark, PhD - Professor, A. Agarwal, PhD - Senior Scientist; Univ. of Mississippi, University, MS. 3:15 p.m. M-1062 Unmasking the Contribution of Oral Mycobiome to the Biofilm Accretion-Endotrach Occlusion During Mechanical Ventilation Using 18S Detection

M. Ghannoum, PhD - Professor

1 , C. Waters, MS - Lead Tech 2 , H. Mot- lagh, MPH - Research Associate 2 , A. Wilson, MD - Director 2 , J. Thomas, PhD - Professor 2 ; 1 Case Western Reserve, Cleveland, OH, 2 West Virginia Univ., Morgantown, WV. 3:30 p.m. M-1063 Neurological Disease After Mold Exposure, Immune Risks Response to Biofilm-Focused Antifungal Therapy J. F. Rini, MS, I. H. Grant, MD- Clinical Assistant Professor, Department of Family and Community Medicine; New York Med. Coll., Valhalla, NY. ------------------------------------------------------------------------ 116T Slide Session Infections in Transplant Recipients Monday, 1:30 p.m.–4:00 p.m. . . . . . . . . . . . . . . . . . . . Room 120 UAN: 0391-9999-12-088-L04-P Moderators: Emily Blumberg, MD - Professor of Medicine Univ. of Pennsylvania, Philadelphia, PA. Shahid Husain, MD - Associate Professor of Medicine, Director of Transplant Infectious Diseases Univ. of Toronto, Toronto, Canada. Objectives: Upon the completion of this Slide Session, the participant should be able to: Identify the impact of respiratory viruses on transplant recipient; Review newer diagnostic strategies for diagnosing post-transplant infec- tions; and Recognize the impact of CMV on post-transplant outcome. Presentations: 1:30 p.m. T-1064 Incidence of Viral Infections in Patients with Lung Trans- plantation P. Bridevaux, MD, MS - Dr 1 , J. Aubert, MD - Professor 2 , G. Wagner, RN - Research assistant 1 , L. Kaiser, MD - Professor 1 ; 1 Univ. Hosp. of Geneva, Geneva, Switzerland, 2 Ctr. Hosp. Univ. Vaudois, Lausanne, Switzerland. 114 SCIENTIFIC SESSIONS September 9-12 | 1:45 p.m. T-1065 Bronchiolitis obliterans following Respiratory Viral Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients D. P. Shah, MD, MSPH - Pre-Doctoral Fellow, A. M. Alousi, MD - As- sistant Professor, L. Bashoura, MD - Associate Professor, P. K. Shah, MD, MSPH - Research Assistant, S. Mahajan, MD - Graduate Research Assis- tant, V. E. Mulanovich, MD - Assistant Professor, E. Ariza-Heredia, MD - Assistant Professor, R. F. Chemaly, MD, MPH, FACP - Associate Professor; MD Anderson Cancer Ctr., Houston, TX. 2:00 p.m. T-1066 Histoplasmosis Following Solid Organ Transplantation

M. A. Assi, MD - Clinical Associate Professor