tuberculosis in Healthcare icaac 2012 finalprogram web4a

285 ORAL SESSIONS Final Program Oral Sessions- Cateogry K Healthcare-Associated and Surgical Infections and Clinical Epidemiology Sunday PM Slide Session 048 Difficulties of Clostridium difficile Room 254 4:00 p.m. - 6:30 p.m. Monday AM Meet-the-Experts 053 Infection Prevention and Control in Low- and -Middle- Resource Settings Esplanade Ballroom 308 7:00 a.m. - 8:15 a.m. Meet-the-Experts 054 Top Papers in Infection Prevention and Control, 2011-2012 Room 120 7:00 a.m. - 8:15 a.m. Symposium 068 Preventing Spread of

M. tuberculosis in Healthcare

Facilities Room 122 8:30a.m. - 10:30 a.m. Slide Session 074 Multidrug- Resistant Organisms and Catheter-Related Infections Room 254 8:30 a.m. - 11:00 a.m. Interactive Symposium 076 Challenges in Infection Control Room 104 11:15 a.m. - 12:45 p.m. Monday PM Interactive Symposium 118 Evidence-Based Infection Preven- tion and Control: Answering Key Questions Room 104 2:00 p.m. - 4:00 p.m. Slide Session 129 Staphylococcus aureus: Tough Bug, Tough Treatment Room 132 2:00 p.m. - 4:00 p.m. Meet-the-Experts 136 Preventing Line-Associated Bloodstream Infec- tion: Which Mea- sures are Essential? Esplanade Ballroom 308 5:45 p.m. - 7:00 p.m. Tuesday AM Meet-the-Experts 138a MDRO Control: What to Do When Basic Prevention Measures Don’t Work? Room 102 7:00 a.m. - 8:15 a.m. Meet-the-Experts 144 Antimicrobial Resistance and Antimicrobial Stewardship in Non- Hospital Settings Room 120 7:00 a.m. - 8:15 a.m. Symposium 193 Regional Approaches to Prevention of Healthcare-Associ- ated Antimicrobial Resistance Esplanade Ballroom 300 11:15 a.m. - 12:45 p.m. Slide Session 199 Bloodstream Infections: Catheters, Cultures and Counts Room 121 11:15 a.m. - 12:45 p.m. Tuesday PM Symposium 208 Are Prevalence Surveys Still Useful for Healthcare- Associated Infection Surveillance? Esplanade Ballroom 305 2:00 p.m. - 4:00 p.m. Meet-the-Experts 217 Challenging Issues in Pediatric Infection Preven- tion and Control Room 122 5:45 p.m. - 7:00p.m. Meet-the-Experts 218 Issues in the Diagnosis and Management of Prosthetic Joint Infections Esplanade Ballroom 310 5:45 p.m. - 7:00 p.m. Wednesday AM Meet-the-Experts 223 Environmental Cleaning and Infection Prevention Room 120 7:00 a.m. - 8:15 a.m. Symposium 231 A Multifac- eted Approach to Preventing Surgical Site Infections Room 121 9:15 a.m. - 11:15 a.m. Slide Session 239 Antimicrobial Stewardship: Perils of Prescribing Esplanade Ballroom 310 9:15 a.m. - 11:45 a.m 286 Oral Sessions September 9-12 | Oral Sessions- Category L1 Clinical Trials of Adults with Community-Acquired Infections Oral Sessions- Category L Clinical Treatment and Outcome Trials Involving Adult Community-Acquired Infections, Including Obstetrical-Gyneco- logical and Sexually Transmitted Infections Sunday PM Monday AM Meet-the-Experts 056 Difficult to Manage Cutaneous Infections in Adults and Children Esplanade Ballroom 302 7:00 a.m. - 8:15 a.m. Symposium 070 New Insights in Diabetic Foot Infections and Osteomyelitis Room 121 8:30 a.m. - 10:30 a.m. Tuesday AM Slide Session 158 New Insights in Bacterial Meningitis Esplanade Ballroom 309 8:30 a.m. - 11:00 a.m. Tuesday PM Symposium 210 Potluck: The Latest on Foodborne Infections Room 132 2:00 p.m. - 4:00 p.m. Wednesday AM Symposium 232 What’s New with Pneumococcus? Esplanade Ballroom 308 9:15 a.m. - 11:15 a.m. Wednesday PM Symposium 045 An Update on Perinatal Infections Room 130 4:00 p.m. - 6:00 p.m. Sunday PM Symposium 044 An Update on Novel and Important Tickborne Diseases Room 102 4:00 p.m. - 6:00 p.m. Monday AM Meet-the-Experts 055 Challenging Infections in Older Adults Esplanade Ballroom 310 7:00 a.m. - 8:15 a.m. Symposium 069 New Issues in the Management of MDRXDR TB Esplanade Ballroom 306 8:30 a.m. - 10:30 a.m. Symposium 078 50 Years of Fluoroquinolones: Past, Present and Future Room 132 11:15 a.m. - 12:45 p.m. Symposium 079 An Update on Streptococcal Pharyngitis and Rheumatic Fever Esplanade Ballroom 302 11:15 a.m. - 12:45 p.m. Monday PM Symposium 127 New Issues in the Management of Multidrug- Resistant MDR Endocarditis Esplanade Ballroom 305 2:00 p.m. - 4:00 p.m. Tuesday AM Symposium 153 Dangerous Pets and Other Animals Room 102 8:30 a.m. - 10:30 a.m. Symposium 154 What Every Clinician Should Know About Emerging New Antimicrobials Esplanade Ballroom 305 8:30 a.m. - 10:30 a.m. Symposium 194 Emerging and Current Challenges in Injecting Drug Users Room 102 11:15 a.m. - 12:45 p.m. Tuesday PM Wednesday AM 287 ORAL SESSIONS Final Program Oral Sessions- Category L2 STD, Urinary Tract and Ob-Gyn Infections Oral Sessions- Category M Mycology, Including Resistance and Mechanisms of Action of Antifungals Sunday PM Monday AM Symposium 071 An Update on the Treatment and Prevention of UTIs Room 102 8:30 a.m. - 10:30 a.m Monday PM Tuesday AM Tuesday PM Wednesday AM Sunday PM Symposium 046 Mycology 2012: Top Papers Room 132 4:00 p.m. - 6:00 p.m. Monday AM Meet-the-Experts 057 Fungal Infections Involving the Eye Room 102 7:00 a.m. - 8:15 a.m. Symposium 072 Research in Mycology: Hot Topics Room 132 8:30 a.m. - 10:30 a.m. Monday PM Slide Session 115 Sleuthing in Mycology Esplanade Ballroom 310 1:30p.m. - 4:00 p.m. Symposium 128 Fungal Infections in High-Risk Groups: Current and Future Strategies for Control Esplanade Ballroom 302 2:00 p.m. - 4:00 p.m. Tuesday AM Interactive Symposium 146 Challenging Cases in Mycology Room 104 8:30 a.m. - 10:30 a.m. Slide Session 159 Mycology for the Bedside Room 122 8:30 a.m. -1:00 a.m. Tuesday PM Meet-the-Experts 219 How Can the Mycology Lab Work for You? Room 121 5:45p.m. -7:00 p.m. Wednesday AM Meet-the-Experts 224 Fungal Infections of the Central Nervous System Room 121 7:00 a.m. - 8:15 a.m. Symposium 233 Controversies in Clinical Mycology Esplanade Ballroom 300 9:15 a.m. - 11:15 a.m. 288 Oral Sessions September 9-12 | Oral Sessions- Category T Transplantation Infectious Diseases Oral Sessions- Category V Virology Non-HIV, Including Resistance, and Non-HIV Viral Opportunistic Infections in HIV-Infected Patients Oral Sessions- Category P Global Health, Travel Medicine and Parasitology Sunday PM Monday AM Monday PM Slide Session 116 Infections in Transplant Recipients Room 120 1:30 p.m. - 4:00 p.m. Tuesday AM Tuesday PM Wednesday AM Sunday PM Interactive Symposium 034 Transplantation and the ID Physician: Management Strategies for the 21st Century Room 104 4:00 p.m. - 6:00 p.m. Monday AM Meet-the-Experts 059 Persistent Herpes Virus Viremia: What Does it Mean? Esplanade Ballroom 300 7:00 a.m. - 8:15 a.m. Symposium 080 Hot Topics in Viral Hepatitis Room 130 11:15 a.m. - 12:45 p.m. Monday PM Slide Session 117 Respiratory Viruses and Measles Esplanade Ballroom 309 1:30 p.m. - 4:00 p.m. Meet-the-Experts 138 New Strategies for Transplantation of HIV Infected Individuals Esplanade Ballroom 300 5:45 p.m. - 7:00 p.m. Tuesday AM Slide Session 160 Hepatitis and Herpes Viruses Room 254 8:30 a.m. - 11:00 a.m. Symposium 195 Influenza: Beyond the Headlines Room 130 11:15 a.m. - 12:45 p.m. Tuesday PM Symposium 212 Viruses and the Central Nervous System: Diagnostic, Treatment and Recent Outbreaks Room 130 2:00 p.m. - 4:00 p.m. Wednesday AM Symposium 235 Recognizing and Managing Anti- viral Resistance Room 120 9:15 a.m. - 11:15 a.m. Sunday PM Interactive Symposium 033 What’s Hot Where it’s Hot: Interactive Cases in Tropical Medicine Room 103 4:00 p.m. - 6:00 p.m. Monday AM Meet-the-Experts 058 Top Ten Papers in Travel and Tropical Medicine Esplanade Ballroom 306 7:00 a.m. - 8:15 a.m. Slide Session 075 Parasitology, Global Health and Travel Medicine Esplanade Ballroom 309 8:30 a.m. - 11:00 a.m. Monday PM Interactive Symposium 119 Clinical Problem Solving: Interactive Cases in Travel and Tropical Medicine Room 103 2:00 p.m. - 4:00 p.m. Meet-the-Experts 137 Controversies in Pre-Travel Prepara- tion Room 122 5:45 p.m. - 7:00 p.m. Tuesday AM Symposium 155 Update on Drug Resistance in Malaria Esplanade Ballroom 310 8:30 a.m. - 10:30 a.m. Tuesday PM Symposium 211 Global Health as an Academic Discipline Esplanade Ballroom 310 2:00 p.m. - 4:00 p.m. Wednesday AM Symposium 234 Best Practices for Serologic Testing in Selected Parasitic Diseases Room 254 9:15 a.m. - 11:15 a.m. 289 POSTER SESSIONS Final Program Poster Session- Category A Antimicrobial Pharmacokinetics, Pharmacodynamics and General Pharmacology Poster Session- Category B Therapy in Animal Models, Pathogenesis of Infectious Diseases, Molecular Basis for Pathogenicity, and Host Defenses Poster Session- Category C1 Antibacterials: Mechanisms of Action, Biochemistry and Genetics of Resistance Antibacterial, not Viral or Fungal Poster Session- Category C2 Antibacterials: Surveys andor Molecular Epidemiology of Resistance and Resistance Genes, Strains or Serotypes Bacterial, not Viral or Fungal Resistance Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 003 PKPD of Carbapenems With or Without Beta-Lactamase Inhibitors 004 Polymyxins and Aminoglycosides: Optimizing PKPD and Dosing Monday 11:15 a.m. - 1:15 p.m. Halls A-C 082 Glycopeptides and Lipopeptides: What’s New in PKPD and Safety 083 Improving Pharmaco- dynamics of Beta-Lactams and Beta-Lactamase Inhibitors Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 161 Clinical Pharmacology of Antiviral and Anti- Tuberculosis Agents 162 Clinical Pharmacology of Novel Anti-Infective Agents 163 Pharmacokinetics Pharmacodynamics of New and Old Oxazolidinones Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 240 Antifungals: Improving PKPD and Safety 241 Toxicokinetics and PKPD of New and Old Fluoroquinolones Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 005 Immune Response to Microbial Infection Monday 11:15 a.m. - 1:15 p.m. Halls A-C 084 Antimicrobial Therapy in Animal Models I Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 164 Antimicrobial Therapy in Animal Models II 165 Microbial Determinants of Virulence Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 006 Carbapenemases and Expanded Spectrum ơ- Lactamases: Enterobacteriaceae, S. aeruginosa, A. bumannii Monday 11:15 a.m. - 1:15 p.m. Halls A-C 085 Genetics and Resistance 086 Resistance by Efflux Quinolone Resistance Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 166 Resistance to Staphylococcus and Other Gram-Positive Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 242 Mechanisms of Resistance to Novel Compounds Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 007 AmpCs: Not Going Away 008 Carbapenemases: Will They Ever End 009 ESBLs: Still Relevant 010 Multi-Center Surveillance Studies Monday 11:15 a.m. - 1:15 p.m. Halls A-C 087 Diverse Resistance Issues in Enterobacteriaceae 088 Food, Animals and Environment Reservoirs for Gram-Negative Organisms 089 Pseudomonas aeruginosa: An Overview of Survelliance Data Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 167 Characterization of Streptococcus pneumoniae in the Era of Antibiotics and Vaccines 168 Drug-Resistant Mycobacterium tuberculosis 169 MRSA: A Bug with Interna- tional Appeal and Great Sense Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 243 Antimicrobial Resistance of Miscellaneous Bacteria 244 Streptococcus and Enterococus 290 Poster Sessions September 9-12 | Poster Session- Category D Laboratory Tests for Diagnosing Infections; Methods for Antibacterial Susceptibility Testing Poster Session- Category E In Vitro Antibacterial Susceptibility Studies and Drug-Combination Interactions Poster Session- Category F New Antimicrobial Agents i.e. pre-US IND or prior to the start of any clinical therapeutic studies and New Research Technologies Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 011 Clostridium difficile Diagnosticss 012 Diagnosis of Infections of Implantable Devices and Biofilms 013 Diagnosis of Respiratory Tract Infections 014 Serologic Methods for Detection of Infectious Diseases Monday 11:15 a.m. - 1:15 p.m. Halls A-C 090 MALDI-ToF Mass Spec- trometry and Identification and Susceptibility Testing 091 Mycobacteria: Diagnostics and Susceptibility Testing 092 Phenotypic Susceptibility Testing Methods Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 170 Detection of Bacteremia and Biomarkers for Sepsis 171 Diagnosis, Characterization and Antimicrobial Susceptibility Testing: Gram-Positive Cocci 172 Molecular Methods for Pathogen Identification and Resistance Detection Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 015 In Vitro Activity of Beta- Lactamase Inhibitor Combinations 016 In Vitro Activity of Fluoroquinolones Monday 11:15 a.m. - 1:15 p.m. Halls A-C 093 Cornucopia of In Vitro Activity 094 In Vitro Activity Against Multidrug-Resistant Gram- Negative Bacteria 095 In Vitro Activity Versus Anaerobes Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 173 In Vitro Activity of Lipoglycopeptides and Related Compounds 174 In Vitro Activity Versus Staphylococcal Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 245 In Vitro Activity for Mycobacteria Sunday 11:30 a.m. - 1:30 p.m. Monday 11:15 a.m. - 1:15 p.m. Halls A-C 096 New Antifungal Agents 097 New Antiviral Agents 098 New Approaches in Mycobac- terial Therapy 099 Targeting the Bacterial Cell Wall: New Beta-Lactams and Beta-Lactamase Inhibitor Combi- nations Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 175 Antimicrobial Peptides and Peptidomimetics 176 Compounds and Approaches for Combating Gram-Positive Infections 177 Novel Antimicrobial Approaches and Agents Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 246 New Ways with Old Friends: Repurposing and Novel Formulations 247 Novel Inhibitors of Bacterial GyrBParE Topoisomerase Subunits 248 Quinolones and Beyond 249 Targeting Gram-Negative Pathogens 291 POSTER SESSIONS Final Program Poster Session- Category G Adult and Pediatric Vaccine Studies and Pediatric Infection Poster Session- Category G3 Studies Relating to Aspects of Pediatric Infections Poster Session- Category H HIVAIDS and Other Retroviruses, Including Resistance Poster Session- Category K Healthcare-Associated and Surgical Infections and Clinical Epidemiology Sunday 11:30 a.m. - 1:30 p.m. Monday 11:15 a.m. - 1:15 p.m. Halls A-C 100 Impact of Expanded Valent: Pneumococcal Vaccines 101 Updates in Vaccines Tuesday 11:15 a.m. - 1:15 p.m. Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Monday 11:15 a.m. - 1:15 p.m. Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 178 Pediatrics Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 017 Adherence to HIV Therapy and Care 018 Hepatitis B and C Coinfection in HIV 019 Opportunistic Infections and Co-Morbid Conditions in HIV-I Monday 11:15 a.m. - 1:15 p.m. Halls A-C 102 Antiretroviral Therapy Outcomes Including Select Populations 103 Safety and Toxicity of Antiretroviral Therapy Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 179 HIV-I Pathogenesis and Predictors of Antiretroviral Response in Treatment and Prevention 180 HIV-I Resistance, Tropism and Novel Laboratory Methods Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 020 Antibiotic Stewardship and Usage 021 Infection Control and the Environment 022 Prosthetic Joint Infections 023 Surgical Site Infections 024 Vancomyoin-Resistant Enterococci Monday 11:15 a.m. - 1:15 p.m. Halls A-C 104 Blood Stream Infections 105 Clostridium difficile Infections 106 Endocarditis 107 Fungal Infections 108 Influenza Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 181 Extended-Spectrum ơ-Lactamase Enterobacteriaceae 182 MRSA Infections 183 Resistant Acinetobacter Infections 184 Resistant Gram-Negative Infections 185 Use of Vancomycin, Daptomycin andor Linezolid Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 250 Bone Infections 251 Hand Hygiene 252 Vascular Catheter and Device Related Infections 253 Ventilator-Associated Pneumonia 292 Poster Sessions September 9-12 | Poster Session- Category L1 Clinical Trials of Adults with Community-Acquired Infections Poster Session- Category L2 STD, Urinary Tract and Ob-Gyn Infections Poster Session- Category M Mycology, Including Resistance and Mechanisms of Action of Antifungals Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 025 Antimicrobial Stewardship and OPAT 026 Respiratory Tract Infection Monday 11:15 a.m. - 1:15 p.m. Halls A-C 109 An Update on Tuberculosis 110 Zoonotic Infections Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 186 Endocarditis and Other Inva- sive Infections 187 Meningitis and Central Ner- vous System Infections 188 Methicillin-Resistant Staphy- lococcus aureus: Clinical Aspects 189 Novel Agents and Insights in Skin and Soft Tissue Infections Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 254 Bone and Joint Infections Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 027 Studies in Sexually Transmit- ted Infection Monday 11:15 a.m. - 1:15 p.m. Tuesday 11:15 a.m. - 1:15 p.m. Wednesday 9:15 a.m. - 11:15 a.m. Halls A-C 255 Urinary Tract Infection Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 028 Fungal Epidemiology Monday 11:15 a.m. - 1:15 p.m. Halls A-C 111 Experimental Mycology Tuesday 11:15 a.m. - 1:15 p.m. Halls A-C 190 Clinical Mycology I 191 Clinical Mycology II Wednesday 9:15 a.m. - 11:15 a.m. 293 POSTER SESSIONS Final Program Poster Session- Category T Transplantation Infectious Diseases Poster Session- Category V Virology Non-HIV, Including Resistance, and Non-HIV Viral Opportunistic Infections in HIV-Infected Patients Poster Session- Category P Global Health, Travel Medicine and Parasitology Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 029 Infections in Transplant Recipients: Viruses and Fungi Monday 11:15 a.m. - 1:15 p.m. Halls A-C 113 Infections in Transplant Recipients and Patients with Malignancies Tuesday 11:15 a.m. - 1:15 p.m. Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Halls A-C 030 Non-HIV Virology Monday 11:15 a.m. - 1:15 p.m. Tuesday 11:15 a.m. - 1:15 p.m. Wednesday 9:15 a.m. - 11:15 a.m. Sunday 11:30 a.m. - 1:30 p.m. Monday 11:15 a.m. - 1:15 p.m. Halls A-C 112 Global Health, Parasitology and Travel Medicine Tuesday 11:15 a.m. - 1:15 p.m. Wednesday 9:15 a.m. - 11:15 a.m. 294 September 9-12 | Not es Notes 295 LATE-BREAKER SCIENTIFIC SESSIONS Final Program 003 A Poster Session PKPD of Carbapenems With or Without Beta-Lacta- mase Inhibitors Sunday, 11:30 AM - 1:30 PM . . . . . . . . . . . . . . . . . . . . . Halls A-C Presentation: A-022a Efficacy of Humanized Carbapenem Exposures against New Delhi Metallo-Beta-Lactamase NDM-1 Producing Enterobacte- riaceae in a Murine Infection Model

D. E. Wiskirchen

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