albicans CA in a Toll-Deficient Model of Invasive Candidiasis IC E. Lewis Finn

108 SCIENTIFIC SESSIONS September 9-12 | M-972 Hyperthermia Sensitizes Rhizopus oryzae Ro to Posacon- azole PCZ and Itraconazole ICZ Action Through Apoptosis

F. Shirazi

1 , M. Pontikos 1 , R. Lewis 1 , S. Achi 1 , T. Walsh 2 , N. Albert 1 , D. Kontoyiannis 1 ; 1 UT MD Anderson Cancer Ctr., Houston, TX, 2 Cornell Univ., New York, NY. M-973 CBS Domain-Containing Proteins are Rhizopus oryzae Ferrioxamine Receptors

M. Liu

1 , T. Ghebremariam 1 , C. Skory 2 , J. E. Edwards, Jr. 1 , A. S. Ibrahim 1 ; 1 Habor-UCLA Med. Ctr., Torrance, CA, 2 USDA, Peoria, IL. M-974 Thermokinetic Evaluation of Fluconazole, Caspofungin, Anidulafungin and Amphotericin B on Planktonic and Biofilm Candida spp. by Microcalorimetry

E. Maiolo

1 , F. Ulrika 1 , S. Dominique 2 , T. Andrej 1 ; 1 Univ. Hosp., Lausanne, Switzerland, 2 Inst. of Microbio. Lausanne, Switzerland. M-975 Mutational Analysis of a Major Multi-Drug Transporter Cdr1p of Pathogenic Candida albicans Reveals Novel Insights into Drug Binding and Transport

M. Rawal Scholar, R. Prasad; Jawaharlal Nehru Univ., New Delhi, India. M-976

Impact of Iron Chelators on Growth and Expression of Iron-Related Genes of Cryptococcus Species M. Chayakulkeeree, T. Tangkoskul Asistant, S. Tiengrim Associate, S. Onsomearng; Siriraj Hosp., Mahidol Univ., Bangkok, Thailand. M-977 The Antifungal Activity of an Abbreviated Regimen of Amphotericin B Deoxycholate DAmB For Cryptococcal Meningitis is Due to Persistence of Drug in the Brain Rather Than T-Cell Recruitment

J. Livermore

1 , A. Sharp 1 , C. Walker 1 , W. Moser 1 , L. Gregson 1 , J. Good- win 1 , T. W. Felton 1 , S. J. Howard 1 , W. Mueller 1 , J. Perfect 2 , W. W. Hope 1 ; 1 The Univ. of Manchester, Manchester, United Kingdom, 2 Duke Univ., Durham, NC. M-978 Caspofungin Induces Apoptosis of Candida albicans at Minimum Inhibitory Concentration MIC and Causes Necrosis at MIC B. Hao 1 , S. Cheng 1 , C. Clancy 2 , M. Nguyen 1 ; 1 Univ. of Pittsburgh, Pittsburgh, PA, 2 Univ. of Pittsburgh and VA Pittsburgh, Pittsburgh, PA. M-979 Effects of Conditional Expression of Cell Wall Synthesis- Encoding Genes in

C. albicans CA in a Toll-Deficient Model of Invasive Candidiasis IC

R. E. Lewis

1 , N. D. Albert 2 , K. Young 3 , C. M. Douglas 3 , D. P. Kontoyiannis 2; 1 Univ. of Houston Coll. of Pharmacy, Houston, TX, 2 The Unvi. of Texas M.D. Anderson Cancer Ctr., Houston, TX, 3 Merck Res. Lab., Kenilworth, NJ. M-980 Evaluation of Arasertaconazole Nitrate Efficacy in a Vaginal Candidiasis Rat Model F. Cabello, DVM , N. Marti, D. Gargallo, A. Guglietta; Res. and Dev. Ctr.. Ferrer Internacional SA, Barcelona, Spain. M-981 Antifungal Activity, Plasma Pharmacokinetics and Safety of Second-Generation Echinocandin ASP9726 in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits

V. Petraitis

1 , R. Petraitiene 1 , K. A. Such 2 , P. W. Moradi 1 , G. E. Strauss 1 , E. Petraityte 1 , S. Fleener 3 , S. Akamatsu 4 , S. Matsumoto 4 , T. J. Walsh, Trans- plantation 1 ; 1 Weill Cornell Med. Coll. of Cornell Univ., New York, NY, 2 The Rockefeller Univ., Weill Cornell Med. Coll., and Mem. Sloan-Kettering Cancer Ctr., New York, NY, 3 Covance Res. Products, Denver, PA, 4 Astellas Pharma Inc., Tukuba, Ibaraki, Japan. M-982 P-Glycoprotein Pgp and Amphotericin B AmB

M. Martinez

1 , V. Chen 1 , K. V. Clemons 1 , M. Johansen 1 , T. Blaschke 1 , L. Zhu 2 , D. A. Stevens 1 ; 1 Stanford Univ., Stanford, CA, 2 Fudan Univ., Shanghai, China. M-983 pH Signaling Inhibition in Candida albicans Leads to Enhanced Activity and Restore Fungicidal Effect of Ergosterol Synthesis Inhibitors S. Sahli 1 , S. Boulahfa 1 , M. Cornet 1,2 ; 1 Univ. Joseph Fourier, Grenoble, France, 2 CHU, Grenoble, France. M-984 In Vitro Immunopharmacodynamics of Cell Wall Active Antifungals against Candida albicans and Aspergillus fumigatus

R. E. Lewis

1 , G. Liao 1 , K. Young 2 , C. M. Douglas 2 , D. P. Kontoyiannis 3 ; 1 Univ. of Houston Coll. of Pharmacy, Houston, TX, 2 Merck Co, Ke- nilworth, NJ, 3 The Univ. of Texas M.D. Anderson Cancer Ctr., Houston, TX. M-985 Impaired Mitochondrial Function in Fluconazole FLC Heteroresistant Candida glabrata

T. Finn

1 , A. Novikov 1 , O. Zimmerman 1 , Y. Paran 1 , N. Osherov 2 , R. Ben- Ami 1 ; 1 Tel Aviv Med. Ctr., Tel Aviv, Israel, 2 Tel Aviv Univ., Tel Aviv, Israel. M-986 Isolation and Characterization of Small Colony Variants of Pseudomonas aeruginosa from Monomicrobial and P. aeruginosa- Aspergillus fumigatus Mixed Microbial Biofilms

E. K. Manavathu, D. L. Vager, J. A. Vazquez; Henry Ford Hosp., Detroit, MI. M-987