B. Méar H. Broquet Kumar coli, Salmonella, Clostridium and Hepatitis C Virus HCV S. Sundsmo, H. Chow, M. Sagermann; Stellar Biotechnologies, Inc., Port Hueneme, CA.

40 SCIENTIFIC SESSIONS September 9-12 | A-034 Risk Factors for and Incidence of Nephrotoxicity Associated with Intravenous Colistin in the Modern Era: A Systematic Review H. Pulluru, K. S. Kaye, J. M. Pogue, D. Marchaim, K. Hayakawa; Detroit Med. Ctr., Wayne State Univ., Detroit, MI. A-035 Pharmacokinetics of Colistin Methanesulfonate and Colistin after Lung Transplantion in Cystic Fibrosis Patients N. Grégoire 1 , F. Périn-Dureau 2 , P. Gobin 3 , C. Cerf 4 , D. Grenet 2 , F. Parquin 2 , O. Mimoz 3 , W. Couet 1,5 ; 1 Univ. of Poitiers, Poitiers, France, 2 Hosp. Foch, Suresnes, France, 3 CHU Poitiers, Poitiers, France, 4 Hosp. Foch, Suresnes, France, 5 Inserm, Poitiers, France. A-036 Plasma Pharmacokinetics and Sputum Concentrations of Colistin After Nebulisation or Intravenous Administration of Colistin Methansulphonate CMS to Ambulatories Cystic Fibrosis Patients S. Marchand 1 , A. Henriet 2 , N. Grégoire 1 , P. Gobin 1 , P. Diot 2 , W. Couet 1,3 ; 1 Univ. of Poitiers, Poitiers, France, 2 CHU Tours, Tours, France, 3 Inserm, Poitiers, France. A-037 Plasma Pharmacokinetics and Epithelial Lining Fluid ELF Concentrations of Colistin after Nebulisation or Intravenous Administration of Colistin Methanesulfonate CMS in Critical Care Patients M. Boisson 1 , S. Marchand 2 , N. Grégoire 2 , P. Gobin 1 , O. Mimoz 1 , W. Couet 2,3 ; 1 CHU Poitiers, Poitiers, France, 2 Univ. of Poitiers, Poitiers, France, 3 Inserm, Poitiers, France. A-038 Penetration of Arbekacin Sulfate to the Lung Tissue Y. Funatsu, N. Hasegawa, H. Nahmgunn, H. Fujiwara, T. Asami, T. Betsuyaku, S. Iwata; Keio Univ., Shinjuku-Ku, Japan. A-039 Pharmacologic Assessment of Guidelines on Gentamicin Use in Infective Endocarditis G. Beraud, A. Elsendoorn, C. Landron, C. Plouzeau, G. Le Moal, C. Godet, C. Burucoa, F. Roblot; Univ. Hosp. of Poitiers, Poitiers, France. A-040 Plazomicin PLZ Compared with Cefepime, Ciprofloxacin, Meropenem, Piperacillin-Tazobactam and Aminoglycosides for the Empiric Treatment of Gram-Negative, including Multidrug- Resistant MDR, Pathogens Causing Infections in Hospitals

S. Zelenitsky

1 , R. Ariano 2 , C. Lawson 1 , G. Zhanel 1 ; 1 Univ. of Manitoba, Winnipeg, Canada, 2 St. Boniface Gen. Hosp., Winnipeg, Canada. A-041 Pharmacodynamics of Plazomicin in a Neutropenic Murine Pneumonia Model against Klebsiella pneumoniae Kpn

A. Louie

1 , S. Fikes 1 , W. Liu 1 , B. VanScoy 1 , R. Cirz 2 , G. Drusano 1 ; 1 Univ. of Florida, Orlando, FL, 2 Achaogen, Inc., South San Francisco, CA. A-042 Dose-Response Efficacy of Plazomicin in the Treatment of Murine Pneumonia Due to 7 Strains of Klebsiella pneumoniae Kpn Including Strains Resistant to Legacy Aminoglycosides

A. Louie

1 , W. Liu 1 , S. Fikes 1 , B. VanScoy 1 , R. Cirz 2 , R. Cass 2 , J. McKin- nell 2 , P. Nordmann 3 , G. Drusano 1 ; 1 Univ. of Florida, Orlando, FL, 2 Achao- gen, Inc., South San Francisco, CA, 3 South Paris Med. Sch., Hosp. Bicetre, Paris, France. ---------------------------------------------------------------------------------- 005 B Poster Session Immune Response to Microbial Infection Sunday, 11:30 a.m.–1:30 p.m. . . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: B-043 Staphylococcus aureus Nasal Carriage Might be Associated with Vitamin D Receptor Polymorphisms in Type 2 Diabetes D. Dimopoulou, I. Messaritakis, G. Samonis, G. Goulielmos, J. Papadakis, G. Brentzos, C. Choulaki, M. Fragaki, A. Valachis, D. P. Kofteridis; Univ. Hosp. of Heraklion, Heraklion, Greece. B-044 Pattern Recognition Receptor Polymorphisms and the Suscep- tibility to Complicated Skin and Skin Structure Infections

M. H. T. Stappers

1,2 , Y. Thys 1,3 , M. Oosting 1 , T. S. Plantinga 1 , M. Ioana 1 , P. Reimnitz 4 , J. W. Mouton 1,2 , M. G. Netea 1 , L. A. B. Joosten 1 , I. C. Gyssens 1,2,3 ; 1 Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Nether- lands, 2 Canisius Wilhelmina Hosp., Nijmegen, Netherlands, 3 Hasselt Univ., Diepenbeek, Belgium, 4 Bayer Healthcare Pharmaceuticals, Wuppertal, Germany. B-045 Role of Mannose-Binding Lectin MBL in Hospitalized- Children Infected with H1N1 2009 Virus in Argentina S. D. Ruvinsky, J. Gurevich, A. Monaco, G. Perez, L. Sen, R. Bologna, A. Mangano; Hosp. de Pediatria Dr. Juan P. Garrahan, Buenos Aires, Argentina. B-046 Immunization of Rats with Recombinant Lactococcus lactis Expressing ClfA Protects from Staphylococcus aureus Experimental Endocarditis Induced by Low-Grade Bacteremia T. R. Veloso, Y. A. Que, M. Giddey, J. Vouillamoz, P. Moreillon, J. Entenza; Univ. of Lausanne, Lausanne, Switzerland. B-047 Leptin-Stat3 Signaling Axis Enhances Colonic Inflammation During Clostridium difficile Infection Withdrawn B-048 Macrolides Inhibit Fusobacterium nucleatum-Induced MUC5AC Induction in Human Airway Epithelial Cells K. Nagaoka, K. Yanagihara, Y. Harada, K. Yamada, Y. Migiyama, Y. Morinaga, S. Kohno; Nagasaki Univ. Hosp., Nagasaki, Japan. B-049 Azithromycin Inhibit Muc5ac Induction by Multidrug- Resistant Acinetobacter baumannii in Airway Epithelial Cells K. Yamada, K. Yanagihara, Y. Harada, Y. Migiyama, K. Nagaoka, Y. Morinaga, K. Izumikawa, H. Kakeya, Y. Yamamoto, S. Kohno; Nagasaki Univ., Nagasaki, Japan. B-050 Lung Sensitization by Candida Albicans Protects from Pseudomonas aeruginosa-Induced Lung Injury Through Expression of Antimicrobial Peptides

J. B. Méar

1 , E. Faure 1 , E. Kipnis 1 , P. Gosset 2 , G. Schurtz 1 , K. Faure 1 , B. Guery 1 ; 1 Faculte de Med. de Lille, Lille, France, 2 Inserm U1019, Team 8, Lille, France. B-051 Natural Killer Cells are Critical in Controlling Pseudomonas aeruginosa Strain PAO1 in a Mice Pneumonia Infection Model

A. H. Broquet

1 , A. Roquilly 1,2 , C. Jacqueline 1 , J. Caillon 1 , G. Potel 1 , K. Asehnoune 1,2 ; 1 UPRES EA3826, Nantes, France, 2 CHU Nantes, Pôle Anes- thésie Réanimations, Service d’Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France. 41 SUNDAY SCIENTIFIC SESSIONS Final Program B-052 T-Cells from Chronic Bone Infection Show Reduced Prolif- eration and a High Proportion of CD28 Negative CD4 T-Cells

G. Kumar

1 , M. Ticchioni 2 , E. Bernard 2 , C. Trojani 2 , P. Roger 2 ; 1 Univ. of Nice Sophia Antipolis, Nice, France, 2 Hopital L’Archet 1, Nice, France. B-053 Keyhole Limpet Hemocyanin KLH N-Glycans Share Similar Structural Features with Saccharides of Schistosoma, Trypano- soma, Leishmania, Cryptococcus, Aspergillis, Candida,

E. coli, Salmonella, Clostridium and Hepatitis C Virus HCV

J. S. Sundsmo, H. Chow, M. Sagermann; Stellar Biotechnologies, Inc., Port Hueneme, CA.

B-054 Monophosphoryl Lipid a Modulates the Cross-Talk Between Dendritic Cells and Natural Killer Cells in a Murine Model of Hemorrhage-Induced Immune Dysfunction A. Roquilly, A. Broquet, C. Jacqueline, R. Cinotti, X. Ambrosi, G. Potel, J. Caillon, K. Asehnoune; Univ. de Nantes, Laboratoire EA UPRES 3826, Nantes, France. B-055 Endotoxemia in Humans Induces Alterations in the T-Cell Compartment and is Associated with Impaired Production of Proinflammatory Cytokines A. Ronit, R. P. Plovsing, J. C. Gaardbo, R. M. Berg, H. J. Hartling, H. Ullum, K. Moller, S. D. Poulsen; Copenhagen Univ. Hosp. Rigshospitalet, Osterbro, Denmark. B-056 Critical Roles of IL-17 in Lethality of Community-Associated MRSA Pneumonia in Mice

Y. Shibue