coli O104:H4, Campylobacter spp. and Other Foodborne Pathogens Scott Miesel M. Zhu Wang

153 TUESDAY SCIENTIFIC SESSIONS Final Program F-1491 Antimicrobial Activity of Two New Peptides S2-P082090 and S5-P082090 against Gram-Positive and -Negative Bacteria: Comparison with Omiganan P. Maffia 1 , D. Faccone 2 , O. Veliz 2 , B. Bogado 1 , L. Semorile 1 , A. Corso 2 ; 1 Univ. Nacional de Quilmes, Buenos Aires, Argentina, 2 Antimicrobianos, Inst. Natl. de Enfermedades Infecciosas-ANLIS, Bueno Aires, Argentina. F-1492 Antimicrobial Activity Upon Planktonic Cells and Biofilms Of Polyethyleneimine J. Barros 1 , P. A. Ramalho 2 , C. Pina-Vaz 2 , A. G. Rodrigues 2 , I. Pina-Vaz 2 ; 1 Faculty of Dentistry, Porto, Portugal, 2 Faculty of Med., Porto, Portugal. F-1493 Small, Nonpeptidic Mimics of Host Defense Proteins Exhibit Potent Killing Activity against Gram-Positive and Gram-Nega- tive Biofilm Cultures

R. W. Scott, M. Corrigan; PolyMedix, Inc., Radnor, PA. F-1494

Nonpeptidic Mimics of Host Defense Proteins as Antimi- crobial Agents for

E. coli O104:H4, Campylobacter spp. and Other Foodborne Pathogens

R. Scott

1 , S. Mithal 1 , C. Chen 2 ; 1 PolyMedix, Inc., Radnor, PA, 2 USDA ARS, Wyndmoor, PA. F-1495 Nonpeptidic Mimics of Host Defense Proteins as Antimicro- bial Agents for Category A and B Biowarefare Pathogens

R. Scott

1 , S. Mithal 1 , C. L. Marchand, III 2 , S. Halasohoris 2 , L. Miller 2 ; 1 PolyMedix, Inc., Radnor, PA, 2 USAMRIID, Frederic, MD. Late-breaker presentations are listed behind the Late-breaker tab of the Final Program. ------------------------------------------------------------------------ 176 F Poster Session Compounds and Approaches for Combating Gram- Positive Infections Tuesday, 11:15 a.m.–1:15 p.m. . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: F-1496 M676, a Putative Inhibitor of Undecaprenyl Pyrophosphate Synthase, Synergizes with ơ-Lactam Antibiotics against MRSA

L. Miesel

1 , J. Baysarowich 2 , A. Caron 3 , J. Huber 2 , M. Kavana 1 , J. Lafleur 3 , P. T. Meinke 2 , D. B. Olsen 4 , R. E. Painter 1 , M. J. Salvatore 2 , M. Szymonif- ka 2 , C. M. Tan 1 , S. T. Waddell 2 , H. Wang 1 , K. Young 1 , S. Singh 2 ; 1 Merck Res. Labs, Kenilworth, NJ, 2 Merck Res. Labs, Rahway, NJ, 3 Merck Res. Labs, Kirkland, Canada, 4 Merck Res. Labs, West Point, PA. F-1497 Antibacterial Spectrum of Oxazolidinone MRX-I: Potent Activity against Multidrug-Resistant Gram-Positive Pathogens

D. M. Zhu

1 , W. Wang 2 , Y. Q. Huang 3 , Y. Y. Zhang 1 ; 1 HuaShan Hosp., Fudan Univ., Shanghai, China, 2 MicuRx Pharmaceuticals Inc., Hayward, CA, 3 MicuRx Pharmaceuticals Inc., Shanghai, CA. F-1498 Antimicrobial Profile of MRX-I: Resistance and Drug Com- bination Studies Y. Li 1 , H. L. Wang 1 , Y. H. Xu 1 , W. Wang 2 , Y. Q. Huang 1 , Q. Wang 1 , J. Liu 2 ; 1 MicuRx Pharmaceuticals Inc., Shanghai, China, 2 MicuRx Pharmaceu- ticals Inc., Hayward, CA. F-1499 Novel Oxazolidinone MRX-I is Efficacious in Mouse Models of Gram-Positive Bacterial Infections

C. R. Li

1 , G. Q. Li 1 , X. X. Hu 1 , W. X. Zhang 1 , X. K. Wang 1 , J. Pang 1 , X. Lu 1 , Q. Q. Zhai 1 , H. Yuan 2 , M. F. Gordeev 3 , X. Y. Yang 1 , X. F. You 1 ; 1 Inst. of Medicinal Biotechnology, Chinese Academy of Med. Sci. Peking Union Med. Coll., Beijing, China, 2 MicuRx Pharmaceuticals Inc., Shanghai, China, 3 MicuRx Pharmaceuticals Inc., Hayward, CA. F-1500 Pre-Clinical Pharmacokinetics of MRX-I in Rodents and Dogs

X. Y. Chen

1 , Z. W. Gao 1 , H. Yuan 2 , Z. Y. Yuan 3 , D. F. Zhong 1 ; 1 Shanghai Inst. of Materia Medica, Chinese Academy of Sci., Shanghai, China, 2 MicuRx Pharmaceuticals Inc., Shanghai, China, 3 MicuRx Pharmaceuticals Inc., Hayward, CA. F-1501 In Vitro Safety Study of MRX-I, a Safer Oxazolidinone Antibiotic Agent

W. Wang

1 , Z. Wang 2 , Y. Chang 2 , H. Yuan 3 , Z. Y. Yuan 1 , J. L. Zhou 4 , D. F. Zhong 4 ; 1 MicuRx Pharmaceuticals Inc., Hayward, CA, 2 Natl. Shanghai Ctr. For Drug Safety Evaluation Res., Shanghai, China, 3 MicuRx Pharma- ceuticals Inc., Shanghai, China, 4 Shanghai Inst. of Materia Medica, Chinese Academy of Sci., Shanghai, China. F-1502 Single-Dose and Repeat-Dose Toxicity of MRX-I in Rat

Y. L. Qiu