Zelenitsky Louie Louie H. T. Stappers

40 SCIENTIFIC SESSIONS September 9-12 | A-034 Risk Factors for and Incidence of Nephrotoxicity Associated with Intravenous Colistin in the Modern Era: A Systematic Review H. Pulluru, K. S. Kaye, J. M. Pogue, D. Marchaim, K. Hayakawa; Detroit Med. Ctr., Wayne State Univ., Detroit, MI. A-035 Pharmacokinetics of Colistin Methanesulfonate and Colistin after Lung Transplantion in Cystic Fibrosis Patients N. Grégoire 1 , F. Périn-Dureau 2 , P. Gobin 3 , C. Cerf 4 , D. Grenet 2 , F. Parquin 2 , O. Mimoz 3 , W. Couet 1,5 ; 1 Univ. of Poitiers, Poitiers, France, 2 Hosp. Foch, Suresnes, France, 3 CHU Poitiers, Poitiers, France, 4 Hosp. Foch, Suresnes, France, 5 Inserm, Poitiers, France. A-036 Plasma Pharmacokinetics and Sputum Concentrations of Colistin After Nebulisation or Intravenous Administration of Colistin Methansulphonate CMS to Ambulatories Cystic Fibrosis Patients S. Marchand 1 , A. Henriet 2 , N. Grégoire 1 , P. Gobin 1 , P. Diot 2 , W. Couet 1,3 ; 1 Univ. of Poitiers, Poitiers, France, 2 CHU Tours, Tours, France, 3 Inserm, Poitiers, France. A-037 Plasma Pharmacokinetics and Epithelial Lining Fluid ELF Concentrations of Colistin after Nebulisation or Intravenous Administration of Colistin Methanesulfonate CMS in Critical Care Patients M. Boisson 1 , S. Marchand 2 , N. Grégoire 2 , P. Gobin 1 , O. Mimoz 1 , W. Couet 2,3 ; 1 CHU Poitiers, Poitiers, France, 2 Univ. of Poitiers, Poitiers, France, 3 Inserm, Poitiers, France. A-038 Penetration of Arbekacin Sulfate to the Lung Tissue Y. Funatsu, N. Hasegawa, H. Nahmgunn, H. Fujiwara, T. Asami, T. Betsuyaku, S. Iwata; Keio Univ., Shinjuku-Ku, Japan. A-039 Pharmacologic Assessment of Guidelines on Gentamicin Use in Infective Endocarditis G. Beraud, A. Elsendoorn, C. Landron, C. Plouzeau, G. Le Moal, C. Godet, C. Burucoa, F. Roblot; Univ. Hosp. of Poitiers, Poitiers, France. A-040 Plazomicin PLZ Compared with Cefepime, Ciprofloxacin, Meropenem, Piperacillin-Tazobactam and Aminoglycosides for the Empiric Treatment of Gram-Negative, including Multidrug- Resistant MDR, Pathogens Causing Infections in Hospitals

S. Zelenitsky

1 , R. Ariano 2 , C. Lawson 1 , G. Zhanel 1 ; 1 Univ. of Manitoba, Winnipeg, Canada, 2 St. Boniface Gen. Hosp., Winnipeg, Canada. A-041 Pharmacodynamics of Plazomicin in a Neutropenic Murine Pneumonia Model against Klebsiella pneumoniae Kpn

A. Louie

1 , S. Fikes 1 , W. Liu 1 , B. VanScoy 1 , R. Cirz 2 , G. Drusano 1 ; 1 Univ. of Florida, Orlando, FL, 2 Achaogen, Inc., South San Francisco, CA. A-042 Dose-Response Efficacy of Plazomicin in the Treatment of Murine Pneumonia Due to 7 Strains of Klebsiella pneumoniae Kpn Including Strains Resistant to Legacy Aminoglycosides

A. Louie

1 , W. Liu 1 , S. Fikes 1 , B. VanScoy 1 , R. Cirz 2 , R. Cass 2 , J. McKin- nell 2 , P. Nordmann 3 , G. Drusano 1 ; 1 Univ. of Florida, Orlando, FL, 2 Achao- gen, Inc., South San Francisco, CA, 3 South Paris Med. Sch., Hosp. Bicetre, Paris, France. ---------------------------------------------------------------------------------- 005 B Poster Session Immune Response to Microbial Infection Sunday, 11:30 a.m.–1:30 p.m. . . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: B-043 Staphylococcus aureus Nasal Carriage Might be Associated with Vitamin D Receptor Polymorphisms in Type 2 Diabetes D. Dimopoulou, I. Messaritakis, G. Samonis, G. Goulielmos, J. Papadakis, G. Brentzos, C. Choulaki, M. Fragaki, A. Valachis, D. P. Kofteridis; Univ. Hosp. of Heraklion, Heraklion, Greece. B-044 Pattern Recognition Receptor Polymorphisms and the Suscep- tibility to Complicated Skin and Skin Structure Infections

M. H. T. Stappers

1,2 , Y. Thys 1,3 , M. Oosting 1 , T. S. Plantinga 1 , M. Ioana 1 , P. Reimnitz 4 , J. W. Mouton 1,2 , M. G. Netea 1 , L. A. B. Joosten 1 , I. C. Gyssens 1,2,3 ; 1 Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Nether- lands, 2 Canisius Wilhelmina Hosp., Nijmegen, Netherlands, 3 Hasselt Univ., Diepenbeek, Belgium, 4 Bayer Healthcare Pharmaceuticals, Wuppertal, Germany. B-045 Role of Mannose-Binding Lectin MBL in Hospitalized- Children Infected with H1N1 2009 Virus in Argentina S. D. Ruvinsky, J. Gurevich, A. Monaco, G. Perez, L. Sen, R. Bologna, A. Mangano; Hosp. de Pediatria Dr. Juan P. Garrahan, Buenos Aires, Argentina. B-046 Immunization of Rats with Recombinant Lactococcus lactis Expressing ClfA Protects from Staphylococcus aureus Experimental Endocarditis Induced by Low-Grade Bacteremia T. R. Veloso, Y. A. Que, M. Giddey, J. Vouillamoz, P. Moreillon, J. Entenza; Univ. of Lausanne, Lausanne, Switzerland. B-047 Leptin-Stat3 Signaling Axis Enhances Colonic Inflammation During Clostridium difficile Infection Withdrawn B-048 Macrolides Inhibit Fusobacterium nucleatum-Induced MUC5AC Induction in Human Airway Epithelial Cells K. Nagaoka, K. Yanagihara, Y. Harada, K. Yamada, Y. Migiyama, Y. Morinaga, S. Kohno; Nagasaki Univ. Hosp., Nagasaki, Japan. B-049 Azithromycin Inhibit Muc5ac Induction by Multidrug- Resistant Acinetobacter baumannii in Airway Epithelial Cells K. Yamada, K. Yanagihara, Y. Harada, Y. Migiyama, K. Nagaoka, Y. Morinaga, K. Izumikawa, H. Kakeya, Y. Yamamoto, S. Kohno; Nagasaki Univ., Nagasaki, Japan. B-050 Lung Sensitization by Candida Albicans Protects from Pseudomonas aeruginosa-Induced Lung Injury Through Expression of Antimicrobial Peptides

J. B. Méar