Sambanthamoorthy, N. Pattabiraman, C. Luo; Walter Reed Army Inst. of Res., Silver Spring, MD. Baugh, L. J. V. Piddock, M. A. Webber; Univ. of Birmingham, Birming- ham, United Kingdom. Fyfe, J. A. Sutcliffe, T. H. Grossman; Tetraphase Pharmaceuticals, Wate

90 SCIENTIFIC SESSIONS September 9-12 | B-662 In Vitro Activity of Cadazolid ACT-179811 against Clostridi- um difficile and in an In Vitro Gut Model of C. difficile infection S. Baines, G. Crowther, S. Todhunter, J. Freeman, M. Wilcox; Leeds Teach- ing Hosp. Univ. of Leeds, Leeds, United Kingdom. B-663 Effects of Vancomycin and Huo Xiang Zheng Qi Liquid on Clostridium difficile Infection in C57BL Mice

M. Chen

1,2 , L. Zhai 1 , K. Schonning 3 , L. P. Andersen 1 , W. A. Alpizar 4 , O. D. Laerum 4 , A. Friis-Moeller 3 ; 1 Rigshospitalet, Copenhagen,, Denmark, 2 Sonderjylland Hosp., Aabenraa, Denmark, 3 Univ. Hosp. Hvidovre, Copen- hagen,, Denmark, 4 The Finsen Ctr., Copenhagen,, Denmark. B-664 Efficacy Comparison between LFF571 and Fidaxomicin in the Hamster Model of Clostridium difficile Infection

D. McKenney

1 , A. Williams 2 , M. LaMarche 2 , J. Praestgaard 3 , J. Leeds 1 ; 1 Novartis Inst.s for BioMed. Res., Emeryville, CA, 2 Novartis Inst. for BioMed. Res., Cambridge, MA, 3 Novartis, East Hanover, NJ. ------------------------------------------------------------------------ 085 C1 Poster Session Genetics and Resistance Monday, 11:15 a.m.–1:15 p.m. . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: C1-665 High Levels of Mobile Quinolone Resistance Genes Found Near a Waste Water Treatment Plant Serving Antibiotic Manu- facturers

C. Rutgersson

1 , C. Flach 1 , N. Marathe 1,2 , E. Kristiansson 3 , A. Janzon 1 , J. Fick 4 , Y. Shouche 2 , E. Moore 5 , D. G. J. Larsson 1 ; 1 Inst. for Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg Univ., Gothenburg, Sweden, 2 Natl. Ctr. for Cell Sci., Pune Univ., Pune, India, 3 Chalmers Univ. of Tech., Gothenburg, Sweden, 4 Umeå Univ., Umeå, Sweden, 5 The Sahlgrenska Univ. Hosp. Univ. of Gothenburg, Gothenburg, Sweden. C1-666 Regulation of Class 1 Integron Integrase Expression in Biofilm

E. Strugeon

1,2 , M. Ploy 1,2,3 , S. Da Re 1,2 ; 1 Inserm, Limoges, France, 2 Univ. de Limoges, Limoges, France, 3 CHU, Limoges, France. C1-667 Mutator dnaQ Favors the Accumulation of a Double Muta- tion in an E.coli gyrA Mutant in One Step to Yield High-Level Fluoroquinolone Resistance

M. Petschulies, A. Heisig- Senior , P. Heisig; Univ. of Hamburg, Hamburg, Germany.

C1-668 Mobile Element Tn 1721 Associated to Resistance Genes and Disseminated in Clinical and Sewage Samples L. C. Balsalobre, M. Dropa, D. E. Oliveira, G. Matté, M. Matté; Univ. of São Paulo, São Paulo, Brazil. C1-669 First Evidence of DNA Recombinant Activity of ISCR1 A. P. Porto 1 , J. A. Ayala 2 , G. O. Gutkind 3 , J. A. Di Conza 1,3 ; 1 Univ. Nacio- nal del Litoral, Santa Fe, Argentina, 2 Univ. Autónoma de Madrid, Madrid, Spain, 3 Univ. de Buenos Aires, Buenos Aires, Argentina. C1-670 Structural Variations in the Resistance Gene Regions of the Integrative and Conjugative Element ICE Pmu1 from Bovine Pasteurella multocida and Mannheimia haemolytica G. B. Michael 1 , K. Kadlec 1 , M. T. Sweeney 2 , R. W. Murray 2 , J. L. Watts 2 ,

S. P. Schwarz

1 ; 1 Inst. of Farm Animal Genetics FLI, Neustadt-Mariensee, Germany, 2 Pfizer Animal Health, Kalamazoo, MI. C1-671 Role of Transcriptional Regulators of the MarR Family Mul- tiple Antibiotic Resistance in Bacteroides fragilis Susceptibility to Antimicrobial Drugs and Oxydative Stress L. A. Lobo 1 , N. L. P. Iorio 2 , F. L. Teixeira, BS 1 , D. N. S. Silva, BS 1 , E. O. Ferreira 1 , R. M. C. Domingues 1 ; 1 UFRJ, Rio de Janeiro, Brazil, 2 UFF, Rio de Janeiro, Brazil. C1-672 Effect of the Transcriptional Activators SoxS, RobA and RamA on the Expression of the Multidrug Efflux Pump AcrAB- TolC of Enterobacter cloacae

A. Perez

1 , M. Poza 1,2 , J. Aranda 1,2 , C. Latasa 3,4 , M. Tomas 1,2 , I. Lasa 3,4 , G. Bou 1,2 ; 1 Hosp. A Coruña, A Coruña, Spain, 2 Univ. Hosp. A Coruña, A Coruña, Spain, 3 Lab. of Microbial Biofilms-CSIC, Pamplona, Spain, 4 Univ. of Pamplona, Pamplona, Spain. C1-673 Identification of Novel Antibacterials Inhibiting Biofilms in a Broad-Spectrum Manner

K. Sambanthamoorthy, N. Pattabiraman, C. Luo; Walter Reed Army Inst. of Res., Silver Spring, MD.

Late-breaker presentations are listed behind the Late-breaker tab of the Final Program. ------------------------------------------------------------------------ 086 C1 Poster Session Resistance by EffluxQuinolone Resistance Monday, 11:15 a.m.–1:15 p.m. . . . . . . . . . . . . . . . . . . . Halls A-C Presentations: C1-674 Chemical Inhibition of Multidrug-Resistance Efflux Abolishes Biofilm Formation by Salmonella enterica Serovar Typhimurium

S. Baugh, L. J. V. Piddock, M. A. Webber; Univ. of Birmingham, Birming- ham, United Kingdom.

C1-675 Susceptibility of Tetracyclines to TN 1721- and Plasmid RP1d TetA Resistance is Dependent on Expression Level and Not Primary Structure

C. Fyfe, J. A. Sutcliffe, T. H. Grossman; Tetraphase Pharmaceuticals, Water- town, MA.

C1-676 Efflux Mediated Multiresistance in Clinical Isolates of Aci- netobacter baumannii

E. J. Yoon, P. Courvalin, C. Grillot-Courvalin; Inst. Pasteur, Paris, France. C1-677

Biofilm Regulator nuc in Staphylococus aureus is Differentially Regulated and Expressed During In Vitro Antibiotic Treatment

W. Rose

1 , S. Shukla 2 , Z. Ye 2 ; 1 Univ. of Wisconsin, Madison, WI, 2 Marshfield Clinic, Marshfield, WI. C1-678 Putative Mechanism of Resistance Detection of Inquilinus limosus by a Full Genome Sequencing Approach M. Pino 1 , J. Di Conza 1 , S. Revale 2 , G. Gutkind 1 ; 1 Fac. Farm. y Bioq.-UBA, Buenos Aires, Argentina, 2 INDEAR, Rosario, Argentina. C1-679 First Identification of tet31 among Tetracycline-Resistant Porcine Bordetella bronchiseptica K. Kadlec 1 , H. Kaspar, DVM 2 , J. Mankertz 2 , S. P. Schwarz 1 ; 1 Inst. of Farm Animal Genetics FLI, Neustadt-Mariensee, Germany, 2 Federal Office of Consumer Protection and Food Safety BVL, Berlin, Germany. 91 MONDAY SCIENTIFIC SESSIONS Final Program C1-680 Cumulative Resistance to the Novel Lpxc Inhibitor Chir-090 in Pseudomonas aeruginosa: Interplay of Efflux and Non Efflux Mechanisms

A. K. Jones