Changes in Endothelial Function and Microcirculation
6.2.3 Microcirculation and O
2 Supply Smoking-induceddamagetothemicrocirculation,includingtheskinandO 2 supply,hasbeen studiedinhumansandinexperimentalanimals [140–143] .Inparticular,dramaticreactions have been demonstrated in smokers undergoing revascularisation procedures [144, 145] . Likewise,skinnecroseshavebeendescribedinsmokersfollowingcosmeticfacialsurgery [141,146,147] .Theseharmfuleffectswereelicitedbythetoxicconstituentsofcigarette smokeandbyCO,andtoaverymuchsmallerextentbynicotine [9] .Insmokers,skinlaps alsoshowdelayedhealingorfailtosurviveatallsee Chap.7.8 [144,148,149] . Variables Smoking Nicotine Referencenos Plasmaibrinogenconcentration Ý Û [71,128–130,136,137, 157,203–205] PlateletaggregationCO-induced Ý Û [41] Haematocrit Ý Û [71,130,131] Leucocytecount Ý Û [135–137] vonWillebrandfactor Ý Û [136,137] FactorXIIa Ý Û [141] Plasminogen ß Û [128,129] Vascularpermeabilityforibrinogen Ý Û [206–208] Redcelldeformability ß Û [132,133,173] Viscosityplasma,blood Ý Û [71,128,130,131] CO-haemoglobin Ý Û [95] Catecholaminesinbloodandurine Ý Ý ,Û [179,195] Table 6.2 Differencesbetweencigarettesmokingandnicotineadministrationonhaemorheological variables [8] Resultsfromclinicalstudies.Ý:elevated,ß:loworreduced,Û:unchangedornormal Dallaetalstudiesin2004theeffectsofacuteandchronicsmokingonskinmicrovas- cularpropertiesofyounghealthysubjects.Inthisobservationalstudy,usingatotallynon- invasiveapproach,employingcontinuouspalmarmicrovascularlowlaserDopplerand arterialpressuremeasurements,atotalof20healthymalesubjectsninehabitualsmokers and11non-smokers;aged27±1and29±2years,respectivelywereexamined [150] . Measureswereobtainedatbaselineandafteriontophoreticadministrationofacetylcholine ACh, an endothelium-dependent vasodilator and of sodium nitroprusside NP, an endothelium-independentvasodilator.Thestudyshowedthatsmokersshowedsigniicant lowerbaselinemicrovascularresistiveZ0andoscillatoryimpedance,i.e.ZCproperties thannon-smokers.Inthenon-smokersgroup,AChandNPiontophoresisinducedasignii- cant decrease of both Z0 and ZC, before and after smoking one cigarette p 0.02. Conversely,inthesmokersgroup,bothZ0andZCwerenotaffectedbyAChiontophoresis beforeacutesmoking,while,aftersmoking,asigniicantdecreaseofbothZ0andZCp 0.02wasdetectedafterAChchallenge.Thestudyindicatesthatsmokershaveacomplex disruptionofperipheralmicrocirculatoryregulation,includinginappropriaterestingvaso- dilation, impaired endothelium-dependent and independent vasodilation, paradoxical recoveryofendothelium-dependentvasodilationinresponsetoacutesmoking [151] . Inafurtherstudy,theacuteeffectsofsmokingonmicrovascularfunctioninhealthy smokerswasstudiedusingmeasuresofHR,bloodpressure,capillaryrecruitmentduring peakreactivehyperaemiaandendothelium-dependentandendothelium-independentvaso- dilatation of the skin microcirculation with iontophoresis of acetylcholine and sodium nitroprussiderespectivelycombinedwithlaserDopplerluxmetry [151] Itwasfoundthat incomparisonwithshamsmoking,acutesmokingcausedincreasesinHRsmoking,9.3± 4.1beatsmin;sham,−1.3±3.0beatsmin;p0.001andsystolicbloodpressuresmok- ing,6.3±8.8mmHg;sham,0.8±4.4mmHg;p0.05.Also,decreasesinabsolutesmok- ing,−4.9±6.9permm 2 ;sham,0.8±2.1permm2;p=0.01andrelativesmoking,−13.8± 21.4;sham,1.9±6.9;p=0.02capillaryrecruitmentduringpeakreactivehyperaemia; anddecreasesinabsolute[smoking,-62.4±47.7perfusionunitsPU;sham,−30.8±32.6 PU;p=0.04]andrelativesmoking,−147±163;sham,32±225;p=0.07vasodilata- tioncausedbyacetylcholineweredemonstrated.Fromthisstudyitcanbeconcludedthat acute smoking is associated with impaired capillary recruitment during peak reactive hyperaemia and impaired microvascular endothelium-dependent vasodilatation. These indingsmayalsoexplaintheincreasedbloodpressureanddecreasedinsulinsensitivity thathavebeenobservedafteracutesmoking [151] . VascularresponseandO 2 supplyoftheskinanddeepertissuelayerscanbemeasured bylaserDopplerlowmetryandbydeterminingtranscutaneouspartialO2pressurewith platinumelectrodes,asourownresearchhasdemonstrated [9] .Attentionwasdrawnlong agotothedifferencesbetweenthereactionsproducedbycigarettesmokeandbynicotine [152] .Reactivehyperaemiaoccurringafter1–3minocclusionoftheupperarmwitha bloodpressurecuffanditsnormalisationhavebeenfoundtodifferbetweensmokersand non-smokers [9,153,154] ,withreactivehyperaemiainsmokersbeinglessthanthatin non-smokersseeFig. 6.6 :thereasonsforthisarecertainlytobesoughtinvasorespon- sivenessNOproductionandintheviscosityoftheblood,whichinluencesitslowprop- erties [9] . The differences in vasoreactivity were still detectable even after a 6-month observationperiodFig. 6.7 [8] .Forasummaryoftheindingsonthistopic,readersareParts
» Tobacco Plants and Their Origin Use of Tobacco for Religious Purposes
» The Appropriation of Tobacco by Europeans
» Development of the Cigarette
» Objections to Smoking on Health Grounds
» Women Won Over by the Cigarette
» The Medical Use of Tobacco in the Nineteenth Century
» Tobacco Research in the Twentieth Century
» Tobacco Consumption in the Twentieth Century
» Cigarette Smoking in the USA Since 1965
» Cigarette-Related Mortality in Different Countries
» Smokers and Other Risk Factors
» Smoking Behaviour and Educational Level in the EU
» Non-Disclosure of Findings by the Tobacco Industry
» The Cigarette as a Vehicle for Nicotine Release
» Modifications of Nicotine Release
» Maintaining Nicotine Dependence Nicotine and Dependence
» Marketing of Cigarettes with a “Reduced” Health Risk
» Compensatory Behaviour by Smokers
» Optimising Nicotine Release Nicotine and Dependence
» Importance of Absorption Rate
» Ammonium and pH Manipulation
» Cigarettes with Reduced Tar Yield
» Agonists and Antagonists of the nAChR and its Subtypes
» Effects of Nicotine on Receptors in Different Organs
» Metabolic and Hormonal Effects of Nicotine
» Central Nervous System Effects of Nicotine
» Types of Dependence Nicotine Dependence
» Molecular Biological Aspects of Dependence
» Genetic Aspects Nicotine Dependence
» Withdrawal Symptoms Nicotine Dependence
» Immunological Reactions Caused by Cigarette Smoking
» Association Between Smoking and Lung Cancer
» Tobacco-Specific Carcinogens Genetic Factors That Increase the Risk for Bronchial Carcinoma
» The Cytochrome P450 and GST System and Carcinogenesis
» Peptide Receptors, Genetic Factors That Increase the Risk for Bronchial Carcinoma
» Exogenous Factors and Lung Cancer
» Pathophysiology of COPD Cigarette Smoking and COPD
» Genetic Factors Important Risk Factors for COPD
» Occupational and Environmental Factors
» Caveats Concerning the Informative Value of Studies
» Cigarette Smoking and Bronchial Asthma in Adults
» Bronchial Asthma in Children
» Other Lung Diseases Influenced by Cigarette Smoking
» Coronary Artery Disease and Myocardial Infarction
» Changes in Endothelial Function and Microcirculation
» Microcirculation and O Systemic Vascular Changes
» Arteriosclerotic and Inflammatory Vascular Reactions
» Genetic Factors Blood Coagulation and Fibrinolysis
» Nicotine and Ischaemic Heart Disease
» Cognitive Impairment Central Nervous System
» Influence on Cognitive Performance
» Intellectual Impairment in Childhood
» Smoker Personality Profiles and Genetic Inheritance of Smoking
» Peculiarities of the Smoker’s Personality
» Reasons for Increased Cigarette Consumption
» Comorbidity Between Depression and Smoking
» Extent of Cigarette Consumption
» Effects of Smoking in Forms of Dementia
» Smoking and Parkinson’s Disease
» Diabetic Retinopathy Ocular Diseases
» Graves’ Ophthalmopathy Ocular Diseases
» Macular Degeneration Ocular Diseases
» Ocular Tumours Ocular Diseases
» Retinal Detachment Ocular Diseases
» Lipid and Cholesterol Metabolism
» Insulin Resistance Diabetic Nephropathy
» Oesophageal Cancer Gastrointestinal Tract
» Gastrointestinal Ulcers Gastrointestinal Tract
» Cancers of the Gastrointestinal Tract
» Pancreatic Cancer Gastrointestinal Tract
» Toxic Substances and Inducers
» Kidney Cancer Urinary Tract Diseases
» Bladder Cancer Urinary Tract Diseases
» Prostatic Hyperplasia and Prostatic Cancer
» Fertility Disorders Urinary Tract Diseases
» Vitamin D and Oestrogen Metabolism
» Osteoporosis Disorders of Mineral Metabolism and Bone
» Hip Fractures Disorders of Mineral Metabolism and Bone
» Skin Changes Skin and Mucosa
» Skin Tumours Skin and Mucosa
» Breast Cancer Skin and Mucosa
» Effects of Smoking on the Placenta
» Malformations Possibly Caused by Smoking
» Smoking and Sudden Infant Death Syndrome SIDS
» Effects of Nicotine on the Foetus
» Medical Care Costs Attributable to Smoking During Pregnancy
» ETS in the Workplace and at Home
» Fibrinogen Cholesterol Endothelium and Platelets
» Markers of Inflammation Changes at the Molecular and Cellular Level
» Passive Smoking During and After Pregnancy
» Coronary Heart Disease Cardiovascular Disease
» Stroke and Subarachnoid Haemorrhage
» Respiratory Tract in Children and Teenagers
» Bronchial Carcinoma Respiratory Tract
» Indications and Diagnostic Considerations
» Self-Help Interventions by the Smoker
» Physician Advice for Smoking Cessation
» Group Behaviour Therapy Programmes
» Mass Media Communication Strategies
» E-Learning, Email and Internet for Smoking Cessation
» Evaluation of Nicotine Products
» Nicotine Chewing Gum Nicotine
» Nicotine Sublingual Tablet Nicotine Nasal Spray
» Treatment and Dosage Nicotine
» Nicotine Chewing Gum Adverse Events Associated with NRT
» Nicotine Patch Adverse Events Associated with NRT
» Nicotine Nasal Spray Adverse Events Associated with NRT
» Nicotine Inhaler Adverse Events Associated with NRT
» Nicotine Sublingual Tablet Adverse Events Associated with NRT
» Nicotine Lozenge Adverse Events Associated with NRT
» Drug Interactions During Smoking Cessation
» Contraindications for the Use of Nicotine Products
» Nicotine Formulations as OTC Products
» Contraindications and Drug Interactions
» Tranquillisers and Buspirone Other Pharmacotherapies
» Various Antidepressants Other Pharmacotherapies
» Opioid Antagonists Other Pharmacotherapies
» Silver Acetate Other Pharmacotherapies
» Therapeutic Monitoring in Smoking Cessation
» Ischaemic Heart Disease Special Therapeutic Situations
» Pregnancy Special Therapeutic Situations
» Weight Gain Special Therapeutic Situations
» Alcohol Consumption Special Therapeutic Situations
» Organic Depression Organic Depression and Schizophrenia
» Schizophrenic Patients Organic Depression and Schizophrenia
» Interactions Between Cigarette Smoking and Administration of Psychopharmaceuticals
» Pre-operative Smoking Cessation Special Therapeutic Situations
» Social Influence Inoculation Strategy
» Life Skills Strategy Prevention Programmes for Schools
» Class 2000 Health Promotion Programme
» Trier University Health Programme Long-Term Studies
» Role of Teachers in Primary Prevention
» Prevention by Restricting Sales of Tobacco Products to Minors
» Role of the Mass Media in Sales of Tobacco Products to Adolescents
» Role of Government and Community in Primary Prevention
» Effect of Tobacco Industry Advertising Messages
» Tobacco Advertising and Adolescent Smoking Initiation
» Advertising with “Light” Cigarettes
» Smoking Bans in Public Buildings and Public Spaces
» Tobacco Industry, Governmental and Non-governmental Organisations
» Politicians and Their Attitude to Smoking
» Scientists and the Tobacco Industry
» Governmental Control of Toxic Tobacco Constituents
» Bans on Advertising in Various Countries
» Tobacco Industry: Playing Down the Risks of Smoking and Passive Smoking
» Smoking and Non-smoking: Weighing the Benefits
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