Bronchitis and Pneumonia ebooksclub.org Tobacco or Health Physiological and Social Damages Caused by Tobacco Smoking Second Edition
5.6 Other Lung Diseases Influenced by Cigarette Smoking
Thiscategoryprincipallyincludesarespiratorybronchiolitis-associatedinterstitiallungdis- ease [207] andpulmonaryLangerhanscellgranulomatosis [208,209] .Pulmonaryhaemor- rhage associated with Goodpasture’s syndrome type is also signiicantly associated with cigarettesmoking [50] .Womenwithbreastcancerwhosmoketendtodeveloplungmetas- tasesmorefrequentlythannon-smokers [210] .Incontrast,sarcoidosis [211] andallergic pneumonitisoccurmorerarelyinsmokersthaninnon-smokers.Idiopathicpulmonaryibro- sisiscommonamongheavysmokersthanformersmokersOR=−2.3;CI:1.3–3.8vs.1.9 CI:1.3–2.9,andthediseasemayevenhaveitsonsetaftersuddensmokingcessation [73] . Obviously,explanationsforthevariousdiseasesaretobesoughtintheeffectsofsmokingon theinlammatoryprocessesinthelung,onimmunefunctionandonvascularpermeability. Smokersarepresumedtohaveahigherriskthannon-smokersfordeveloping-varicella pneumonia [110,212] .Radiologically,pneumoniacanbedetectedonthebasisofdiffuse interstitialorpatchyiniltratesinupto20ofadultcases [213] ,thoughoftenwithout clinicalsymptoms.Thepulmonarysymptomsusuallysetinduringtheirstdaysafterthe onsetofrash,andconsistofcough,dyspnoeaandvaryingdegreesofhypoxaemiacaused byinlammationandswellingofthebronchialepithelium [206,214] .Inuntreatedadults, themortalityratefromvaricellapneumoniaisapproximately10,butmaybeashighas 50wherethereisseverepulmonaryinvolvementleadingtopulmonaryfailure [206] .5.7 Concluding Remarks
• Currentknowledgeindicatesthatthereisanestablishedassociationbetweensmokingand variousformsoflungcancer.Exposureovermonthsandyearstothevariousinhalational productsoftobacco,suchasbenzo[a]pyrene,nitrosaminesNNK,NNN,solventsben- zene,crotonaldehyde,formaldehydeand 210 polonium,isanimportantaetiologicalfactor. TheorganiccompoundsaremetabolisedactivatedbyvariousenzymesintheCYPsys- temandthenformadductswithDNAinlungtissueandwithleucocytes.Inaddition,the activityoftheGSTsystemplaysanimportantroleinthedetoxiicationeliminationof carcinogens. • Asigniicantriskforthedevelopmentoflungcancerhasbeenidentiiedinindividuals with high inducibility of CYP1A1 and reduced activity of glutathione S-reductase GSTM100.Theriskforbronchialcarcinomaisparticularlyincreasedincarriersofthe GSTM100system.Bronchialcarcinomaiscommonlyencounteredandsome90of casesaresmoking-related;worldwide,itsprevalenceisincreasingmoreamongwomen thanmen. • Asthepracticeofsmokinglightcigaretteshasbecomemorewidespread,therehasbeen anincreaseintheprevalenceofAC,aformoflungcancerthatislessamenabletotreat- mentthanSCC. • Inaddition,COPDoftensustainedbyyearsofsmokingactivityisgainingimportance becauseitiscomplextotreatandisevenmorecommonthanbronchialcarcinoma.In thenearfuture,COPDwillbethethirdmostcommondiseaseworldwide. • IftheyareexposedtoenvironmentaltobaccosmokeETS,childrenareatargetgroup forthedevelopmentoflungdiseases.Asthmaticdiseases,especiallyamongchildren, arenotcausedbypassivesmoking,butaresustainedandacceleratedintheirprogres- sionbysmokeinhalation. References 1.U.S.DepartmentofHealthandHumanServices;PublicHealthServices,CentresforDisease Control1996PHSdocumentno.46-1123 2.CentresforDiseaseControl.1993Mortalitytrendsforselectedsmoking-relatedcancersand breastcancer--UnitedStates,1550-1990.MorbMortalWklyRep42:857;863–866 3.American Thoracic Society 1995 Standards for the diagnosis and care of patients with chronicobstructivepulmonarydisease.AmRevRespirCritCare152:77–121 4.EnvironmentalProtectionAgency1992Respiratoryhealtheffectsofpassivesmoking:lung cancer and other disorders. Ofice of Research and Development, Ofice of Health and EnvironmentalAssessment,Washington,DC.US_EPA,Report-No.EPA6006–90006F 5.BAlSteeringCommittee1990Bronchoalveolarlavageconstituentsinhealthyindividuals, idiopathicpulmonaryibrosis,andselectedcomparisongroups.TheBAlCooperativeGroup SteeringCommittee.AmRevRespirDis141:169–202 6.LaughterAH,MartinRR,TwomeyJJ1977Lymphoproliferativeresponsestoantigensmedi- atedbyhumanpulmonaryalveolarmacrophages.JLabClinMed896:1326–1332 7.IribarrenC,TekawaIS,SidneyS,FriedmanGD1999Effectofcigarsmokingontheriskof cardiovasculardisease,chronicobstructivepulmonarydisease,andcancerinmen.NEngl JMed34023:1773–1780 8.BrownGP,IwamotoGK,MonickMM,HunninghakeGW1989Cigarettesmokingdecreases interleukin1releasebyhumanalveolarmacrophages.AmJPhysiol2562Pt1:C260–C264 9.KlineJN,SchwartzDA,MonickMM,FloerchingerCS,HunninghakeGW1993Relative releaseofinterleukin-1betaandinterleukin-1receptorantagonistbyalveolarmacrophages.A studyinasbestos-inducedlungdisease,sarcoidosis,andidiopathicpulmonaryibrosis.Chest 1041:47–53 10.SolimanDM,TwiggHLIII1992Cigarettesmokingdecreasesbioactiveinterleukin-6secre- tionbyalveolarmacrophages.AmJPhysiol2634Pt1:L471–L478 11.DanieleRP,DauberJH,AltoseMD,RowlandsDT,GorenbergDJ1977Lymphocytestudies inasymptomaticcigarettesmokers.Acomparisonbetweenlungandperipheralblood.AmRev RespirDis1166:997–1005 12.TollerudDJ,ClarkJW,BrownLM,NeulandCY,MannDL,Pankiw-TrostLKetal1989The effectsofcigarettesmokingonTcellsubsets.Apopulation-basedsurveyofhealthyCaucasians. AmRevRespirDis1396:1446–1451 13.MeliskaCJ,StunkardME,GilbertDG,JensenRA,MartinkoJM1995Immunefunctionin cigarettesmokerswhoquitsmokingfor31days.JAllergyClinImmunol954:901–910 14.U.S.DepartmentHealthHumanServices;PublicHealthServices,CentresforDiseaseControl 1982TheHealthbeneitsofsmokingcessation.AreportoftheSurgeonGeneral.PHSdocu- mentno.90-8416Parts
» Tobacco Plants and Their Origin Use of Tobacco for Religious Purposes
» The Appropriation of Tobacco by Europeans
» Development of the Cigarette
» Objections to Smoking on Health Grounds
» Women Won Over by the Cigarette
» The Medical Use of Tobacco in the Nineteenth Century
» Tobacco Research in the Twentieth Century
» Tobacco Consumption in the Twentieth Century
» Cigarette Smoking in the USA Since 1965
» Cigarette-Related Mortality in Different Countries
» Smokers and Other Risk Factors
» Smoking Behaviour and Educational Level in the EU
» Non-Disclosure of Findings by the Tobacco Industry
» The Cigarette as a Vehicle for Nicotine Release
» Modifications of Nicotine Release
» Maintaining Nicotine Dependence Nicotine and Dependence
» Marketing of Cigarettes with a “Reduced” Health Risk
» Compensatory Behaviour by Smokers
» Optimising Nicotine Release Nicotine and Dependence
» Importance of Absorption Rate
» Ammonium and pH Manipulation
» Cigarettes with Reduced Tar Yield
» Agonists and Antagonists of the nAChR and its Subtypes
» Effects of Nicotine on Receptors in Different Organs
» Metabolic and Hormonal Effects of Nicotine
» Central Nervous System Effects of Nicotine
» Types of Dependence Nicotine Dependence
» Molecular Biological Aspects of Dependence
» Genetic Aspects Nicotine Dependence
» Withdrawal Symptoms Nicotine Dependence
» Immunological Reactions Caused by Cigarette Smoking
» Association Between Smoking and Lung Cancer
» Tobacco-Specific Carcinogens Genetic Factors That Increase the Risk for Bronchial Carcinoma
» The Cytochrome P450 and GST System and Carcinogenesis
» Peptide Receptors, Genetic Factors That Increase the Risk for Bronchial Carcinoma
» Exogenous Factors and Lung Cancer
» Pathophysiology of COPD Cigarette Smoking and COPD
» Genetic Factors Important Risk Factors for COPD
» Occupational and Environmental Factors
» Caveats Concerning the Informative Value of Studies
» Cigarette Smoking and Bronchial Asthma in Adults
» Bronchial Asthma in Children
» Other Lung Diseases Influenced by Cigarette Smoking
» Coronary Artery Disease and Myocardial Infarction
» Changes in Endothelial Function and Microcirculation
» Microcirculation and O Systemic Vascular Changes
» Arteriosclerotic and Inflammatory Vascular Reactions
» Genetic Factors Blood Coagulation and Fibrinolysis
» Nicotine and Ischaemic Heart Disease
» Cognitive Impairment Central Nervous System
» Influence on Cognitive Performance
» Intellectual Impairment in Childhood
» Smoker Personality Profiles and Genetic Inheritance of Smoking
» Peculiarities of the Smoker’s Personality
» Reasons for Increased Cigarette Consumption
» Comorbidity Between Depression and Smoking
» Extent of Cigarette Consumption
» Effects of Smoking in Forms of Dementia
» Smoking and Parkinson’s Disease
» Diabetic Retinopathy Ocular Diseases
» Graves’ Ophthalmopathy Ocular Diseases
» Macular Degeneration Ocular Diseases
» Ocular Tumours Ocular Diseases
» Retinal Detachment Ocular Diseases
» Lipid and Cholesterol Metabolism
» Insulin Resistance Diabetic Nephropathy
» Oesophageal Cancer Gastrointestinal Tract
» Gastrointestinal Ulcers Gastrointestinal Tract
» Cancers of the Gastrointestinal Tract
» Pancreatic Cancer Gastrointestinal Tract
» Toxic Substances and Inducers
» Kidney Cancer Urinary Tract Diseases
» Bladder Cancer Urinary Tract Diseases
» Prostatic Hyperplasia and Prostatic Cancer
» Fertility Disorders Urinary Tract Diseases
» Vitamin D and Oestrogen Metabolism
» Osteoporosis Disorders of Mineral Metabolism and Bone
» Hip Fractures Disorders of Mineral Metabolism and Bone
» Skin Changes Skin and Mucosa
» Skin Tumours Skin and Mucosa
» Breast Cancer Skin and Mucosa
» Effects of Smoking on the Placenta
» Malformations Possibly Caused by Smoking
» Smoking and Sudden Infant Death Syndrome SIDS
» Effects of Nicotine on the Foetus
» Medical Care Costs Attributable to Smoking During Pregnancy
» ETS in the Workplace and at Home
» Fibrinogen Cholesterol Endothelium and Platelets
» Markers of Inflammation Changes at the Molecular and Cellular Level
» Passive Smoking During and After Pregnancy
» Coronary Heart Disease Cardiovascular Disease
» Stroke and Subarachnoid Haemorrhage
» Respiratory Tract in Children and Teenagers
» Bronchial Carcinoma Respiratory Tract
» Indications and Diagnostic Considerations
» Self-Help Interventions by the Smoker
» Physician Advice for Smoking Cessation
» Group Behaviour Therapy Programmes
» Mass Media Communication Strategies
» E-Learning, Email and Internet for Smoking Cessation
» Evaluation of Nicotine Products
» Nicotine Chewing Gum Nicotine
» Nicotine Sublingual Tablet Nicotine Nasal Spray
» Treatment and Dosage Nicotine
» Nicotine Chewing Gum Adverse Events Associated with NRT
» Nicotine Patch Adverse Events Associated with NRT
» Nicotine Nasal Spray Adverse Events Associated with NRT
» Nicotine Inhaler Adverse Events Associated with NRT
» Nicotine Sublingual Tablet Adverse Events Associated with NRT
» Nicotine Lozenge Adverse Events Associated with NRT
» Drug Interactions During Smoking Cessation
» Contraindications for the Use of Nicotine Products
» Nicotine Formulations as OTC Products
» Contraindications and Drug Interactions
» Tranquillisers and Buspirone Other Pharmacotherapies
» Various Antidepressants Other Pharmacotherapies
» Opioid Antagonists Other Pharmacotherapies
» Silver Acetate Other Pharmacotherapies
» Therapeutic Monitoring in Smoking Cessation
» Ischaemic Heart Disease Special Therapeutic Situations
» Pregnancy Special Therapeutic Situations
» Weight Gain Special Therapeutic Situations
» Alcohol Consumption Special Therapeutic Situations
» Organic Depression Organic Depression and Schizophrenia
» Schizophrenic Patients Organic Depression and Schizophrenia
» Interactions Between Cigarette Smoking and Administration of Psychopharmaceuticals
» Pre-operative Smoking Cessation Special Therapeutic Situations
» Social Influence Inoculation Strategy
» Life Skills Strategy Prevention Programmes for Schools
» Class 2000 Health Promotion Programme
» Trier University Health Programme Long-Term Studies
» Role of Teachers in Primary Prevention
» Prevention by Restricting Sales of Tobacco Products to Minors
» Role of the Mass Media in Sales of Tobacco Products to Adolescents
» Role of Government and Community in Primary Prevention
» Effect of Tobacco Industry Advertising Messages
» Tobacco Advertising and Adolescent Smoking Initiation
» Advertising with “Light” Cigarettes
» Smoking Bans in Public Buildings and Public Spaces
» Tobacco Industry, Governmental and Non-governmental Organisations
» Politicians and Their Attitude to Smoking
» Scientists and the Tobacco Industry
» Governmental Control of Toxic Tobacco Constituents
» Bans on Advertising in Various Countries
» Tobacco Industry: Playing Down the Risks of Smoking and Passive Smoking
» Smoking and Non-smoking: Weighing the Benefits
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