60
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15
0.029
0.583 1.749
8.745 8.745
1.564 85.902
45.257
30 0.173
3.571 10.712
53.558 55.307
9.890 205.284
45
0.275
5.687 17.060
85.301 97.761
17.481 328.506
60 0.379
7.844 23.533 117.666 147.187
26.319 967.897
90 0.517
10.707 32.122 160.612 213.666
38.207 1254.909
120 0.544
11.268 33.803 169.015 254.191
45.454 2965.311
180
0.578
11.973 35.919 179.595 298.575
53.390 3324.309
240 0.535
11.081 33.243 166.214 321.112
57.420 3484.977
300
0.452
9.359 28.077 140.384 328.525
58.746 3675.361
360 0.452
9.359 28.077 140.384 356.602
63.766
AUC
16292.456
Luas Area 100 36000
b. Replikasi 2 Formula PVP 1
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15
0.098
2.015 6.044
30.218 30.218
4.938 111.993
45.622
30 0.178
3.674 11.023
55.114 61.158
9.994 196.607
45
0.265
5.479 16.438
82.189 99.255
16.220 314.939
60 0.400
8.280 24.840 124.201 157.705
25.772 905.753
90
0.494
10.230 30.691 153.454 211.799
34.612 1147.146
120 0.538
11.143 33.429 167.147 256.183
41.865 2843.599
180
0.648
13.425 40.276 201.380 323.844
52.922 3377.344
240 0.651
13.488 40.463 202.313 365.054
59.656 3686.204
300
0.591
12.243 36.728 183.641 386.844
63.217 3840.359
360 0.504
10.438 31.313 156.566 396.498
64.795
AUC
16432.944
Luas Area 100
36000
Formula PVP 2
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15 0.074
1.517 4.550
22.749 22.749
3.541 102.752
67.799
30
0.196
4.048 12.143
60.716 65.266
10.159 205.439
45 0.303
6.268 18.803
94.015 110.707 17.233
427.221 60
0.707
14.649 43.948 219.741 255.237
39.730 1249.465
61
90 0.645
13.363 40.089 200.446 279.890
43.568 1515.439
120 0.803
16.641 49.923 249.616 369.149
57.462 4004.908
180 0.616
21.268 63.803 319.015 488.471
76.035 5043.171
240 0.692
23.882 71.645 358.226 591.485
92.070 5757.068
300 0.650
22.429 67.288 336.442 641.346
99.832 6102.129
360 0.943
19.546 58.637 293.185 665.378 103.572
AUC
24407.592
Luas Area 100
36000
Formula PVP 3
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15 0.200
4.131 12.392
61.961 61.961
11.080 263.781
75.096
30 0.394
8.156 24.467 122.334 134.726
24.091 465.551
45 0.565
11.703 35.110 175.550 212.409
37.982 568.406
60 0.449
9.297 27.890 139.450 211.419
37.805 1638.849
90 0.964
19.981 59.944 299.720 399.579
71.451 2339.384
120 0.604
20.853 62.558 312.790 472.593
84.508 5173.993
180 0.867
17.969 53.907 269.533 491.894
87.959 5368.050
240 0.748
15.500 46.500 232.500 508.768
90.976 5529.386
300 0.641
13.280 39.840 199.201 521.969
93.337 5687.049
360 0.565
11.703 35.110 175.550 538.158
96.232
AUC
27034.450
Luas Area 100
36000
c. Replikasi 3
Formula PVP 1
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15 0.124
2.554 7.662
38.309 38.309
6.260 181.488
36.244
30
0.329
6.807 20.421 102.106 109.768
17.938 325.375
45 0.411
8.508 25.525 127.624 155.707
25.445 417.923
60 0.424
8.778 26.334 131.670 185.278
30.278 978.222
90 0.431
8.923 26.770 133.849 213.790
34.937 1071.015
120
0.375
7.761 23.284 116.421 223.133
36.464 2259.263
180 0.347
7.180 21.541 107.707 237.703
38.845 2572.089
240
0.436
9.027 27.081 135.405 286.942
46.891 2601.443
300 0.210
4.338 13.015
65.073 243.691 39.823
2640.867 360
0.333 6.890
20.670 103.351 294.983 48.205
AUC
13047.683
62
Luas Area 100
36000
Formula PVP 2
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15
0.076
1.558 4.674
23.371 23.371
3.638 126.876
34.780
30 0.260
5.376 16.127
80.633 85.307
13.279 249.982
45
0.348
7.201 21.604 108.019 128.820
20.052 344.530
60 0.399
8.259 24.778 123.890 166.295
25.885 881.646
90
0.464
9.608 28.824 144.118 211.301
32.891 1055.484
120 0.466
9.649 28.948 144.741 240.747
37.475 2396.736
180
0.475
9.836 29.508 147.541 272.496
42.417 2344.187
240 0.242
5.002 15.006
75.031 229.494 35.723
2296.288 300
0.299
6.185 18.554
92.770 262.239 40.820
2825.040 360
0.498 10.313
30.940 154.699 342.722 53.348
AUC
12520.769
Luas Area 100
36000
Formula PVP 3
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15 0.173
3.571 10.712
53.558 53.558
9.577 247.755
71.150
30
0.388
8.031 24.093 120.467 131.178
23.457 477.655
45 0.612
12.678 38.035 190.176 224.981
40.230 711.645
60
0.749
15.521 46.562 232.811 305.651
54.656 1859.717
90 0.863
17.886 53.658 268.288 387.691
69.326 2211.170
120
0.848
17.575 52.724 263.620 436.680
78.086 4819.402
180 0.759
15.728 47.185 235.923 461.707
82.561 5008.117
240 0.640
13.259 39.778 198.890 471.859
84.376 5147.416
300 0.563
11.662 34.985 174.927 487.674
87.204 5131.122
360
0.390
8.073 24.218 121.089 468.822
83.833
AUC
25613.998
Luas Area 100
36000
d. Rata-rata Data Uji Pelepasan Obat
