70
5 0.614 12.720 635.996 0.636
P2 1 0.794
16.454 822.718 0.823 0.747 0.132 17.704
0.675 110.635
2 0.504 10.438 521.888 0.522
3 0.815 16.890 844.502 0.845
4 0.781 16.185 809.232 0.809
5 0.710 14.712 735.581 0.736
P3 1 0.594
12.305 615.249 0.615 0.509 0.114 22.388
0.672 75.748
2 0.585 12.118 605.913 0.606
3 0.406 8.405 420.228 0.420
4 0.525 10.873 543.672 0.544
5 0.348 7.201 360.062 0.360
d. Stabilitas Minggu II Suhu 45
o
C i. Uji Organoleptis
Formula Warna
Kejernihan Kehalusan
Kelengketan
PVP 1 Kuning
Terdispersi Halus
Kering PVP 2
Kuning Terdispersi
Halus Kering
PVP 3 Kuning
Terdispersi Agak kasar ada
gelembung Kering
ii. Uji Keseragaman Bobot
PVP 1 PVP 2
PVP 3
1 0.0113
0.0083 0.0104
2 0.0112
0.0088 0.0136
3 0.0082
0.0093 0.0049
4 0.0077
0.0092 0.0080
5 0.0100
0.0117 0.0190
6 0.0098
0.0080 0.0096
7 0.0121
0.0115 0.0060
8 0.0139
0.0118 0.0073
9 0.0105
0.0114 0.0121
10 0.0101
0.0112 0.0139
�̅
0.01048 0.01012
0.01048
SD 0.00171
0.00145 0.00406
CV 16.33
14.35 38.75
iii. Uji Ketebalan
PVP 1 PVP 2
PVP 3
1 0.15
0.15 0.15
2 0.15
0.15 0.15
3 0.15
0.15 0.15
71
4 0.15
0.15 0.15
5 0.15
0.15 0.15
�̅ 0.15
0.15 0.15
iv. Uji pH Sediaan
pH
PVP 1 7.1
PVP 2 7.1
PVP 3 7.3
v. Uji Moisture Content dan Moisture Absorption
Bobot awal
Bobot akhir
Bobot akhir
MC �̅
MC SD
CV MA
�̅ MA SD CV
P1 1 0.0113 0.0112 0.0122 0.893
6.315 5.832 92.347 8.929
11.917 2.972 24.943 2 0.0112 0.0111 0.0122
0.901 9.910
3 0.0082 0.0076 0.0084 7.895
10.526 4 0.0077 0.0072 0.0083
6.944 15.278
5 0.0100 0.0087 0.0100 14.943 14.943
P2 1 0.0083 0.0082 0.0089 1.220
5.005 4.363 87.180 8.537
7.213 2.951 40.909
2 0.0088 0.0080 0.0084 10.000 5.000
3 0.0093 0.0092 0.0095 1.087
3.261 4 0.0092 0.0089 0.0097
3.371 8.989
5 0.0117 0.0107 0.0118 9.346
10.280 P3 1 0.0104 0.0103 0.0111
0.971 0.701 0.478 68.175
7.767 10.023 5.156 51.442
2 0.0136 0.0135 0.0146 0.741
8.148 3 0.0049 0.0049 0.0055
0.000 12.245
4 0.0080 0.0079 0.0093 1.266
17.722 5 0.0190 0.0189 0.0197
0.529 4.233
vi. Uji Ketahanan Pelipatan
Frekuensi
PVP 1 45
PVP 2 40
PVP 3 30
vii. Uji Kandungan Obat dalam Sediaan
Formula Abs
Kadar Terukur
µgmL Q Obat
µg Q
Obat mg
�̅ Q Obat
SD CV
Q Obat Teoritis
mg Recovery
P1 1 0.474
9.815 490.768 0.491 0.554 0.036
6.440 0.682
81.178 2 0.556
11.517 575.830 0.576
72
3 0.555 11.496 574.793 0.575
4 0.543 11.247 562.344 0.562
5 0.545 11.288 564.419 0.564
P2 1 0.521
10.790 539.523 0.540 0.540 0.024
4.397 0.675
80.022 2 0.518
10.728 536.411 0.536 3 0.501
10.376 518.776 0.519 4 0.560
11.600 579.979 0.580 5 0.508
10.521 526.037 0.526
P3 1 0.504
10.438 521.888 0.522 0.492 0.159 32.308
0.672 73.185
2 0.295 6.102 305.083 0.305
3 0.339 7.015 350.726 0.351
4 0.597 12.367 618.361 0.618
5 0.640 13.259 662.967 0.663
e. Stabilitas Minggu III Suhu 37
