66
3 0.542
11.226 561.307 0.561 4
0.665 13.778 688.900 0.689
5 0.650
13.467 673.340 0.673
b. Stabilitas Minggu I Suhu 45
o
C i. Uji Organoleptis
Formula Warna
Kejernihan Kehalusan
Kelengketan
PVP 1 Kuning
Terdispersi Halus
Kering PVP 2
Kuning Terdispersi
Halus Kering
PVP 3 Kuning
Terdispersi Agak kasar ada
gelembung Kering
ii. Uji Keseragaman Bobot
PVP 1 PVP 2
PVP 3
1 0.0128
0.0086 0.0088
2 0.0129
0.0105 0.0133
3 0.0126
0.0112 0.0092
4 0.0154
0.0094 0.0098
5 0.0162
0.0090 0.0112
6 0.0145
0.0100 0.0121
7 0.0163
0.0103 0.0053
8 0.0132
0.0109 0.0062
9 0.0113
0.0093 0.0112
10 0.0135
0.0106 0.0083
�̅
0.01387 0.00998
0.00954
SD 0.00158
0.00082 0.00240
CV 11.39
8.24 25.16
iii. Uji Ketebalan
PVP 1 PVP 2
PVP 3
1 0.20
0.15 0.20
2 0.20
0.15 0.20
3 0.20
0.15 0.25
4 0.20
0.15 0.25
5 0.20
0.15 0.20
�̅ 0.20
0.15 0.22
67
iv. Uji pH Sediaan
pH
PVP 1 6.9
PVP 2 7
PVP 3 7
v. Uji Moisture Content dan Moisture Absorption
Bobot awal
Bobot akhir
Bobot akhir
MC �̅
MC SD
CV MA
�̅ MA
SD CV
P1 1 0.0128 0.0127 0.0127 0.787
2.167 2.377 109.70 0.000
1.388 1.597 115.073 2 0.0129 0.0128 0.0130
0.781 1.562
3 0.0126 0.0123 0.0128 2.439
4.065 4 0.0154 0.0145 0.0146
6.207 0.690
5 0.0162 0.0161 0.0162 0.621
0.621 P2 1 0.0086 0.0082 0.0083
4.878 6.685 5.879
87.95 1.220
2.262 2.574 113.765 2 0.0112 0.0101 0.0102 10.891
0.990 3 0.0094 0.0082 0.0083 14.634
1.220 4 0.0100 0.0098 0.0099
2.041 1.020
5 0.0103 0.0102 0.0109 0.980
6.863 P3 1 0.0088 0.0083 0.0083
6.024 2.507 2.313
92.24 0.000
2.433 2.288 94.044
2 0.0092 0.0089 0.0090 3.371
1.124 3 0.0053 0.0052 0.0055
1.923 5.769
4 0.0062 0.0062 0.0063 0.000
1.613 5 0.0083 0.0082 0.0085
1.220 3.659
vi. Uji Ketahanan Pelipatan
Frekuensi
PVP 1 41
PVP 2 45
PVP 3 30
vii. Uji Kandungan Obat dalam Sediaan
Formula Abs
Kadar Terukur
µgmL Q Obat
µg Q
Obat mg
�̅ Q Obat
SD CV
Q Obat Teoritis
mg Recovery
P1 1 0.586
12.139 606.950 0.607 0.608 0.054
8.920 0.682
89.148 2 0.658
13.633 681.639 0.682 3 0.597
12.367 618.361 0.618 4 0.511
10.583 529.149 0.529 5 0.583
12.077 603.838 0.604 P2
1 0.454 9.400 470.021 0.470 0.478 0.075
15.657 0.675
70.770
68
2 0.447 9.255 462.759 0.463
3 0.579 11.994 599.689 0.600
4 0.381 7.886 394.295 0.394
5 0.446 9.234 461.722 0.462
P3 1 0.529
10.956 547.822 0.548 0.504 0.054
10.624 0.672
74.945 2 0.400
8.280 414.004 0.414 3 0.496
10.272 513.589 0.514 4 0.522
10.811 540.560 0.541 5 0.485
10.044 502.178 0.502
c. Stabilitas Minggu II Suhu 37
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