Rata-rata Data Uji Pelepasan Obat Grafik rata-rata release vs waktu pelepasan obat piroksikam Stabilitas Minggu I Suhu 37 Uji Moisture Content dan Moisture Absorption

62 Luas Area 100 36000 Formula PVP 2 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.076 1.558 4.674 23.371 23.371 3.638 126.876 34.780 30 0.260 5.376 16.127 80.633 85.307 13.279 249.982 45 0.348 7.201 21.604 108.019 128.820 20.052 344.530 60 0.399 8.259 24.778 123.890 166.295 25.885 881.646 90 0.464 9.608 28.824 144.118 211.301 32.891 1055.484 120 0.466 9.649 28.948 144.741 240.747 37.475 2396.736 180 0.475 9.836 29.508 147.541 272.496 42.417 2344.187 240 0.242 5.002 15.006 75.031 229.494 35.723 2296.288 300 0.299 6.185 18.554 92.770 262.239 40.820 2825.040 360 0.498 10.313 30.940 154.699 342.722 53.348 AUC 12520.769 Luas Area 100 36000 Formula PVP 3 Waktu menit Abs Kadar sebenarnya µgmL Q obat 3 mL µg Q obat 15 mL µg Q kum µg release AUC DE 15 0.173 3.571 10.712 53.558 53.558 9.577 247.755 71.150 30 0.388 8.031 24.093 120.467 131.178 23.457 477.655 45 0.612 12.678 38.035 190.176 224.981 40.230 711.645 60 0.749 15.521 46.562 232.811 305.651 54.656 1859.717 90 0.863 17.886 53.658 268.288 387.691 69.326 2211.170 120 0.848 17.575 52.724 263.620 436.680 78.086 4819.402 180 0.759 15.728 47.185 235.923 461.707 82.561 5008.117 240 0.640 13.259 39.778 198.890 471.859 84.376 5147.416 300 0.563 11.662 34.985 174.927 487.674 87.204 5131.122 360 0.390 8.073 24.218 121.089 468.822 83.833 AUC 25613.998 Luas Area 100 36000

d. Rata-rata Data Uji Pelepasan Obat

Waktu menit Formula PVP 1 Formula PVP 2 Formula PVP 3 15 4.023 3.460 7.407 30 10.557 11.483 19.146 63 45 17.000 19.261 31.898 60 23.697 31.472 39.593 90 30.214 39.124 59.661 120 33.650 49.068 69.349 180 37.967 61.645 74.637 240 43.287 69.148 77.591 300 41.732 75.533 79.762 360 45.100 81.183 81.277 DE360 33.693 53.867 63.834

e. Grafik rata-rata release vs waktu pelepasan obat piroksikam

10 20 30 40 50 60 70 80 90 50 100 150 200 250 300 350 400 Re lea se Waktu Menit Grafik Waktu vs Release Obat Piroksikam Formula 1 Formula 2 Formula 3 64 Lampiran 9. Data Uji Stabilitas Sediaan Hydrocolloid Matrix Piroksikam 1. Data Uji Stabilitas Sediaan

a. Stabilitas Minggu I Suhu 37

o C i. Uji Organoleptis Formula Warna Kejernihan Kehalusan Kelengketan PVP 1 Kuning Terdispersi Halus Kering PVP 2 Kuning Terdispersi Halus Kering PVP 3 Kuning Terdispersi Agak kasar ada gelembung Kering ii. Uji Keseragaman Bobot PVP 1 PVP 2 PVP 3 1 0.0140 0.0164 0.0048 2 0.0137 0.0155 0.0093 3 0.0100 0.0152 0.0072 4 0.0101 0.0187 0.0134 5 0.0111 0.0200 0.0157 6 0.0144 0.0114 0.0169 7 0.0110 0.0179 0.0163 8 0.0081 0.0161 0.0197 9 0.0113 0.0177 0.0192 10 0.0136 0.0173 0.0099 �̅ 0.01173 0.01662 0.01324 SD 0.00199 0.00223 0.00490 CV 16.97 13.43 37.04 iii. Uji Ketebalan PVP 1 PVP 2 PVP 3 1 0.10 0.15 0.15 2 0.10 0.15 0.15 3 0.10 0.15 0.15 4 0.10 0.15 0.15 5 0.10 0.15 0.15 �̅ 0.10 0.15 0.15 iv. Uji pH Sediaan pH PVP 1 7 PVP 2 6.9 PVP 3 6.9 65

v. Uji Moisture Content dan Moisture Absorption

Bobot awal Bobot akhir Bobot akhir MC �̅ MC SD CV MA �̅ MA SD CV P1 1 0.0140 0.0138 0.0141 1.449 4.228 2.839 67.147 2.174 2.673 2.243 83.946 2 0.0137 0.0133 0.0134 3.008 0.752 3 0.0100 0.0092 0.0095 8.696 3.261 4 0.0101 0.0096 0.0102 5.208 6.250 5 0.0111 0.0108 0.0109 2.778 0.926 P2 1 0.0164 0.0149 0.0155 10.067 6.721 2.918 43.423 4.027 2.736 0.917 33.531 2 0.0155 0.0147 0.0150 5.442 2.041 3 0.0152 0.0139 0.0142 9.353 2.158 4 0.0187 0.0177 0.0183 5.650 3.390 5 0.0200 0.0194 0.0198 3.093 2.062 P3 1 0.0048 0.0045 0.0050 6.667 4.051 3.241 79.990 11.111 5.208 3.589 68.926 2 0.0093 0.0086 0.0091 8.140 5.814 3 0.0072 0.0071 0.0074 1.408 4.225 4 0.0134 0.0133 0.0136 0.752 2.256 5 0.0157 0.0152 0.0156 3.289 2.632 vi. Uji Ketahanan Pelipatan Frekuensi PVP 1 105 PVP 2 111 PVP 3 45 vii. Uji Kandungan Obat dalam Sediaan Formula Abs Kadar Terukur µgmL Q Obat µg Q Obat mg �̅ Q Obat SD CV Q Obat Teoritis mg Recovery P1 1 0.513 10.624 531.224 0.531 0.513 0.057 11.202 0.682 75.215 2 0.456 9.442 472.095 0.472 3 0.420 8.695 434.751 0.435 4 0.545 11.288 564.419 0.564 5 0.543 11.247 562.344 0.562 P2 1 0.593 12.284 614.212 0.614 0.560 0.073 12.978 0.675 83.034 2 0.549 11.371 568.568 0.569 3 0.559 11.579 578.942 0.579 4 0.585 12.118 605.913 0.606 5 0.420 8.695 434.751 0.435 P3 1 0.633 13.114 655.705 0.656 0.648 0.050 7.745 0.672 96.464 2 0.639 13.239 661.929 0.662 66 3 0.542 11.226 561.307 0.561 4 0.665 13.778 688.900 0.689 5 0.650 13.467 673.340 0.673

b. Stabilitas Minggu I Suhu 45