62
Luas Area 100
36000
Formula PVP 2
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15
0.076
1.558 4.674
23.371 23.371
3.638 126.876
34.780
30 0.260
5.376 16.127
80.633 85.307
13.279 249.982
45
0.348
7.201 21.604 108.019 128.820
20.052 344.530
60 0.399
8.259 24.778 123.890 166.295
25.885 881.646
90
0.464
9.608 28.824 144.118 211.301
32.891 1055.484
120 0.466
9.649 28.948 144.741 240.747
37.475 2396.736
180
0.475
9.836 29.508 147.541 272.496
42.417 2344.187
240 0.242
5.002 15.006
75.031 229.494 35.723
2296.288 300
0.299
6.185 18.554
92.770 262.239 40.820
2825.040 360
0.498 10.313
30.940 154.699 342.722 53.348
AUC
12520.769
Luas Area 100
36000
Formula PVP 3
Waktu menit
Abs Kadar
sebenarnya
µgmL
Q obat 3 mL
µg
Q obat 15 mL
µg
Q kum
µg
release AUC
DE
15 0.173
3.571 10.712
53.558 53.558
9.577 247.755
71.150
30
0.388
8.031 24.093 120.467 131.178
23.457 477.655
45 0.612
12.678 38.035 190.176 224.981
40.230 711.645
60
0.749
15.521 46.562 232.811 305.651
54.656 1859.717
90 0.863
17.886 53.658 268.288 387.691
69.326 2211.170
120
0.848
17.575 52.724 263.620 436.680
78.086 4819.402
180 0.759
15.728 47.185 235.923 461.707
82.561 5008.117
240 0.640
13.259 39.778 198.890 471.859
84.376 5147.416
300 0.563
11.662 34.985 174.927 487.674
87.204 5131.122
360
0.390
8.073 24.218 121.089 468.822
83.833
AUC
25613.998
Luas Area 100
36000
d. Rata-rata Data Uji Pelepasan Obat
Waktu menit
Formula PVP 1
Formula PVP 2
Formula PVP 3
15 4.023
3.460 7.407
30 10.557
11.483 19.146
63
45 17.000
19.261 31.898
60 23.697
31.472 39.593
90 30.214
39.124 59.661
120 33.650
49.068 69.349
180 37.967
61.645 74.637
240 43.287
69.148 77.591
300 41.732
75.533 79.762
360 45.100
81.183 81.277
DE360 33.693
53.867 63.834
e. Grafik rata-rata release vs waktu pelepasan obat piroksikam
10 20
30 40
50 60
70 80
90
50 100
150 200
250 300
350 400
Re lea
se
Waktu Menit
Grafik Waktu vs Release Obat Piroksikam
Formula 1 Formula 2
Formula 3
64
Lampiran 9. Data Uji Stabilitas Sediaan Hydrocolloid Matrix Piroksikam 1. Data Uji Stabilitas Sediaan
a. Stabilitas Minggu I Suhu 37
o
C i. Uji Organoleptis
Formula Warna
Kejernihan Kehalusan
Kelengketan
PVP 1 Kuning
Terdispersi Halus
Kering PVP 2
Kuning Terdispersi
Halus Kering
PVP 3 Kuning
Terdispersi Agak kasar ada
gelembung Kering
ii. Uji Keseragaman Bobot
PVP 1 PVP 2
PVP 3
1 0.0140
0.0164 0.0048
2 0.0137
0.0155 0.0093
3 0.0100
0.0152 0.0072
4 0.0101
0.0187 0.0134
5 0.0111
0.0200 0.0157
6 0.0144
0.0114 0.0169
7 0.0110
0.0179 0.0163
8 0.0081
0.0161 0.0197
9 0.0113
0.0177 0.0192
10 0.0136
0.0173 0.0099
�̅
0.01173 0.01662
0.01324
SD
0.00199 0.00223
0.00490
CV 16.97
13.43 37.04
iii. Uji Ketebalan
PVP 1 PVP 2
PVP 3
1 0.10
0.15 0.15
2 0.10
0.15 0.15
3 0.10
0.15 0.15
4 0.10
0.15 0.15
5 0.10
0.15 0.15
�̅
0.10 0.15
0.15
iv. Uji pH Sediaan
pH
PVP 1 7
PVP 2 6.9
PVP 3 6.9
65
v. Uji Moisture Content dan Moisture Absorption
Bobot awal
Bobot akhir
Bobot akhir
MC �̅
MC SD
CV MA
�̅ MA
SD CV
P1 1 0.0140 0.0138 0.0141 1.449
4.228 2.839 67.147 2.174
2.673 2.243 83.946 2 0.0137 0.0133 0.0134
3.008 0.752
3 0.0100 0.0092 0.0095 8.696
3.261 4 0.0101 0.0096 0.0102
5.208 6.250
5 0.0111 0.0108 0.0109 2.778
0.926 P2 1 0.0164 0.0149 0.0155 10.067
6.721 2.918 43.423 4.027
2.736 0.917 33.531 2 0.0155 0.0147 0.0150
5.442 2.041
3 0.0152 0.0139 0.0142 9.353
2.158 4 0.0187 0.0177 0.0183
5.650 3.390
5 0.0200 0.0194 0.0198 3.093
2.062 P3 1 0.0048 0.0045 0.0050
6.667 4.051 3.241 79.990
11.111 5.208 3.589 68.926
2 0.0093 0.0086 0.0091 8.140
5.814 3 0.0072 0.0071 0.0074
1.408 4.225
4 0.0134 0.0133 0.0136 0.752
2.256 5 0.0157 0.0152 0.0156
3.289 2.632
vi. Uji Ketahanan Pelipatan
Frekuensi
PVP 1 105
PVP 2 111
PVP 3 45
vii. Uji Kandungan Obat dalam Sediaan
Formula Abs
Kadar Terukur
µgmL Q Obat
µg Q
Obat mg
�̅ Q Obat
SD CV
Q Obat Teoritis
mg Recovery
P1 1
0.513 10.624 531.224 0.531
0.513 0.057 11.202 0.682
75.215 2
0.456 9.442 472.095 0.472
3 0.420
8.695 434.751 0.435 4
0.545 11.288 564.419 0.564
5 0.543
11.247 562.344 0.562
P2 1
0.593 12.284 614.212 0.614
0.560 0.073 12.978 0.675
83.034 2
0.549 11.371 568.568 0.569
3 0.559
11.579 578.942 0.579 4
0.585 12.118 605.913 0.606
5 0.420
8.695 434.751 0.435 P3
1 0.633
13.114 655.705 0.656 0.648 0.050
7.745 0.672
96.464 2
0.639 13.239 661.929 0.662
66
3 0.542
11.226 561.307 0.561 4
0.665 13.778 688.900 0.689
5 0.650
13.467 673.340 0.673
b. Stabilitas Minggu I Suhu 45