68
2 0.447 9.255 462.759 0.463
3 0.579 11.994 599.689 0.600
4 0.381 7.886 394.295 0.394
5 0.446 9.234 461.722 0.462
P3 1 0.529
10.956 547.822 0.548 0.504 0.054
10.624 0.672
74.945 2 0.400
8.280 414.004 0.414 3 0.496
10.272 513.589 0.514 4 0.522
10.811 540.560 0.541 5 0.485
10.044 502.178 0.502
c. Stabilitas Minggu II Suhu 37
o
C i. Uji Organoleptis
Formula Warna
Kejernihan Kehalusan
Kelengketan
PVP 1 Kuning
Terdispersi Halus
Kering PVP 2
Kuning Terdispersi
Halus Kering
PVP 3 Kuning
Terdispersi Agak kasar ada
gelembung Kering
ii. Uji Keseragaman Bobot
PVP 1 PVP 2
PVP 3
1 0.0116
0.0171 0.0087
2 0.0112
0.0123 0.0123
3 0.0115
0.0128 0.0083
4 0.0142
0.0119 0.0090
5 0.0124
0.0116 0.0092
6 0.0127
0.0119 0.0150
7 0.0127
0.0122 0.0137
8 0.0084
0.0111 0.0076
9 0.0141
0.0124 0.0117
10 0.0133
0.0117 0.0082
�̅
0.01221 0.0125
0.01037
SD 0.00160
0.00160 0.00246
CV 13.12
12.78 23.76
iii. Uji Ketebalan
PVP 1 PVP 2
PVP 3
1 0.20
0.25 0.25
2 0.20
0.25 0.25
3 0.20
0.25 0.25
4 0.20
0.25 0.25
5 0.20
0.25 0.25
69
�̅
0.20 0.25
0.25
iv. Uji pH Sediaan
pH
PVP 1 7.4
PVP 2 7.4
PVP 3 7.4
v. Uji Moisture Content dan Moisture Absorption
Bobot awal
Bobot akhir
Bobot akhir
MC �̅
MC SD
CV MA
�̅ MA
SD CV
P1 1 0.0116 0.0114 0.0122 1.754 1.211
0.526 43.449
7.018 6.735
2.819 41.861
2 0.0112 0.0110 0.0112 1.818 1.818
3 0.0115 0.0114 0.0124 0.877 8.772
4 0.0124 0.0123 0.0133 0.813 8.130
5 0.0127 0.0126 0.0136 0.794 7.937
P2 1 0.0171 0.0170 0.0178 0.588 5.459
3.329 60.990
4.706 3.763
1.969 52.313
2 0.0123 0.0115 0.0120 6.957 4.348
3 0.0128 0.0123 0.0125 4.065 1.626
4 0.0119 0.0112 0.0119 6.250 6.250
5 0.0116 0.0106 0.0108 9.434 1.887
P3 1 0.0087 0.0086 0.0092 1.163 0.851
0.944 110.976
6.977 8.579
4.493 52.375
2 0.0123 0.0122 0.0138 0.820 13.115
3 0.0083 0.0083 0.0087 0.000 4.819
4 0.0090 0.0088 0.0100 2.273 13.636
5 0.0092 0.0092 0.0096 0.000 4.348
vi. Uji Ketahanan Pelipatan
Frekuensi
PVP 1 36
PVP 2 35
PVP 3 25
vii. Uji Kandungan Obat dalam Sediaan
Formula Abs
Kadar Terukur
µgmL Q Obat
µg Q
Obat mg
�̅ Q Obat
SD CV
Q Obat Teoritis
mg Recovery
P1 1 0.441
9.131 456.535 0.457 0.596 0.080 13.346
0.682 87.444
2 0.622 12.886 644.295 0.644
3 0.585 12.118 605.913 0.606
4 0.617 12.782 639.108 0.639
70
5 0.614 12.720 635.996 0.636
P2 1 0.794
16.454 822.718 0.823 0.747 0.132 17.704
0.675 110.635
2 0.504 10.438 521.888 0.522
3 0.815 16.890 844.502 0.845
4 0.781 16.185 809.232 0.809
5 0.710 14.712 735.581 0.736
P3 1 0.594
12.305 615.249 0.615 0.509 0.114 22.388
0.672 75.748
2 0.585 12.118 605.913 0.606
3 0.406 8.405 420.228 0.420
4 0.525 10.873 543.672 0.544
5 0.348 7.201 360.062 0.360
d. Stabilitas Minggu II Suhu 45
