54 Tabel 8
. Hasil Evaluasi Granul
Distribusi Ukuran Partikel Tabel 9.
Persen Fraksi Masing-masing Formula
Ukuran Partikel Persen Fraksi
Formula 1 Formula 2
Formula 3 Formula 4
850 µm 3,61
3,72 3,,1
1,2 850 µm - 1 mm
14,97 6,63
8,07 16,44
1 mm - 1,18 mm 75,1
78,3 74,2
69,7 1,18 mm - 1,4 mm
3,82 7,15
7,9 7,18
1,4 mm – 1,7 mm 2,5
4,2 6,73
5,48
Grafik Distribusi Ukuran Partikel No
Pengujian Formula
Syarat 1
2 3
4
1. Kecepatan alir grdtk
5,12 5,4
5,35 5,26
4-10 grdtk 2.
Sudut Henti
o
32,25 19,39 21,80
22,29 ≤30
3.
o
kompresibilitas 17,78
10,2 13,68
15,92 5-15 sangat baik,
12-16 baik, 18-21 cukup baik
5. Kadar Lembab
1,4 2,89
2,75 1,53
2-5
55 • Formula 1
Gambar 9. Grafik Distribusi Ukuran Partikel Formula 1
• Formula 2
Gambar 10. Grafik Distribusi Ukuran Partikel Formula 2
• Formula 3
10 20
30 40
50 60
70 80
850 µm 850 µm - 1
mm 1 mm -
1,18 mm 1,18 mm -
1,4 mm 1,4 mm -
1,7 mm
Fr a
k si
Ukuran Partikel
Formula 1
10 20
30 40
50 60
70 80
90
850 µm 850 µm - 1
mm 1 mm - 1,18
mm 1,18 mm -
1,4 mm 1,4 mm - 1,7
mm
Fr a
k si
Ukuran Partikel
Formula 2
56 Gambar 11.
Grafik Distribusi Ukuran Partikel Formula 3
• Formula 4
Gambar 12. Grafik Distribusi Ukuran Partikel Formula 4
4.1.8 Evaluasi Tablet
10 20
30 40
50 60
70 80
850 µm 850 µm - 1
mm 1 mm -
1,18 mm 1,18 mm -
1,4 mm 1,4 mm -
1,7 mm
Fr a
k si
Ukuran Partikel
Formula 3
10 20
30 40
50 60
70 80
850 µm- 850 µm
850 µm - 1 mm
1 mm - 1,18 mm
1,18 mm - 1,4 mm
1,4 mm - 1,7 mm
Fr a
k si
Ukuran Partikel
Formula 4
57 a.
Organoleptik Tabel 10
.Hasil Pengamatan Organoleptik Tablet Hisap
No Pengamatan Formula
1 2
3 4
1 Bentuk
Bulat Bulat
Bulat Bulat
2 Warna
Kuning Muda
Kuning Muda
Kuning Muda
Kuning Muda
3 Rasa
Manis Manis
Manis Manis
4 Bau
Aroma mint Aroma mint Aroma mint Aroma mint 5
Tekstur Licin
Licin Licin
Licin
b. Keseragaman Bobot
58 Tabel 11
.Hasil Uji Keseragaman Bobot
No Massa tablet hisap gr ±SD
Formula 1 Formula 2
Formula 3 Formula 4
1 2,0990 ± 0,382 2,0254 ± 0,258 2,0788 ± 2,145 2,0071 ± 0,730
2 2,1548 ± 2,265 2,0133 ± 0,853 2,1131 ± 0,530 2,0632 ± 2,043
3 2,0818 ± 1,198 2,0136 ± 0,839 2,1457 ± 1,000
2,0238 ±0,095 4
2,1736 ± 3,157 2,0146 ± 0,789 2,1111 ± 0,624 2,0249 ± 0,149 5
2,1622 ± 2,616 2,0493 ± 0,918 2,1603 ± 1,691 2,0319 ± 0,495 6
2,1428 ± 1,696 2,0130 ± 0,868 2,1176 ± 0,318 2,0413 ± 0,960 7
2,1585 ± 2,441 2,0298 ± 0,041 2,1554 ± 1,460 2,0626 ± 2,014 8
2,2562 ± 7,078 2,0465 ± 0,781 2,1268 ± 0,114 2,0311 ± 0,456 9
2,0027 ± 4,952 2,0116 ± 0,937 2,0547 ± 3,279 1,9988 ± 1,141 10
2,0207 ± 4,098 2,0196 ± 0,543 2,1523 ± 1,314 2,0380 ± 0,797 11
2,1776 ± 3,347 2,0257 ± 0,243 2,1335 ± 0,429 1,9663 ± 2,748 12
2,0983 ± 0,145 2,317 ± 0,052
2,1435 ± 0,900 2,0571 ± 1,742 13
2,0334 ± 3,945 2,0337 ± 0,150 2,0928 ± 1,486 1,9410 ± 4,000 14
2,0866 ± 0,971 2,0487 ± 0,889 2,1799 ± 2,613 2,0596 ± 0,922 15
2,1219 ± 0,704 2,0215 ± 0,450 2,1235 ± 0,041 2,0562 ± 1,697 16
2,1339 ± 1,273 2,0432 ± 0,618 2,1195 ± 0,229 2,0139 ± 0,394 17
2,0391 ± 3,225 2,0292 ± 0,070 2,1688 ±2,091
1,9817 ± 1,987 18
2,0312 ± 3,600 2,0489 ±0,899
2,1075 ± 0,794 2,0011 ± 1,027 19
2,1073 ± 0,011 2,0452 ± 0,717 2,0940 ± 1,429 2,1053 ± 4,126 20
2,0596 ± 2,252 2,0483 ± 0’869 2,1087 ± 0,737 1,9326 ± 4,415 Memenuhi persyaratan
c. Keseragaman Ukuran
59 Tabel 12
.Hasil Uji Keseragaman Ukuran
No Pengukuran
rata-rata Formula
1 2
3 4
1 Diameter mm
20,06715 20,03555
20,0496 20,02795
2 Tebal mm
7,89275 7,71055
7,92595 7,7074
Memenuhi Persyaratan
d. Kekerasan
Tabel 13 .Hasil Uji Kekerasan Tablet Hisap
No Kekerasan kgcm
3
Syarat Formula 1
Formula 2 Formula 3
Formula 4
1 22,23
10,81 11,81
16,78
Memenuhi persyaratan
2 22,01
11,11 11,66
16,35 3
22,31 10,43
11,10 16,26
4 21,21
10,57 11,60
16,27 5
22,21 10,99
11,05 16,94
6 21,66
11,18 11,21
16,62 7
21,60 11,09
11,31 16,37
8 22,00
11,06 11,21
16,51 9
22,05 10,73
11,05 16,08
10 21,73
10,31 11,73
16,43 Rerata
21,901 10,828
11,373 16,46
e. Friabilitas
