Selain itu, monoterpen juga memiliki aktivitas molekuler yang berpotensi untuk mendasari index terapetik yang positif, pada penelitian Gould 1997
dikatakan bahwa monoterpen mampu menghambat isoprenilasi small G protein, isoprenilasi protein memegang peranan penting dalam fungsionalisasi protein
yang mampu memacu terjadinya kanker McTaggart, 2006. Penghambatan ini dapat mengubah sinyal transduksi dan mengakibatkan ekspresi gen yang berubah,
hasil dari ekspresi gen yang baru telah diidentifikasi mampu menurunkan regresi dari karsinoma kelenjar payudara.
47
BAB V KESIMPULAN DAN SARAN
A. Kesimpulan
Ekstrak etanol daun lavender mempunyai efek sitotoksik pada sel kanker payudara T47D serta menginduksi apoptosis dengan nilai IC
50
sebesar 232,86 µgmL dan mampu menekan ekspresi protein ERα.
B. Saran
1. Perlu dilakukan proses pengujian lebih lanjut untuk mengetahui senyawa- senyawa yang terkandung di dalam ekstrak etanol daun L. officinalis Chaix.
2. Potensi ketoksikan dari ekstrak etanol daun L. officinalis Chaix perlu ditingkatkan dengan mengujikannya pada model sel kanker payudara lain.
3. Penelitian dilanjutkan
dengan membuat
suatu formulasi
sediaan menggunakan ekstrak etanol daun Lavandula officinalis Chaix sebagai obat
kemopreventif.
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