Mr. André Friese Dr. Jens Kallmeyer Dr. Carri Ayne Jones Dr. Julia Anne Maresca Ms. Jessica Paulina Roelands

124 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013 analogous to what is known for the earth’s earliest oceans. Our understanding of ecological functioning in the Malili lakes may therefore yield insight into the Earths earliest marine ecosystems.

72.1 Dr. Sean Andrew Crowe

Warga Negara : Kanada Jabatan : Associate Professor Institusi : University of British Columbia No. SIP : 374SIPFRPSMIX2013

72.2 Mr. André Friese

Warga Negara : Jerman Jabatan : Master Student Institusi : University of Postdam No. SIP : 375SIPFRPSMIX2013

72.3 Dr. Jens Kallmeyer

Warga Negara : fghjklJerman Jabatan : Scientist Institusi : GFZ Postdam No. SIP : 376SIPFRPSMIX2013

72.5 Dr. Carri Ayne Jones

Warga Negara : Amerika Serikat Jabatan : Researcher Institusi : University of British Columbia No. SIP : 377SIPFRPSMIX2013 125 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013

72.6 Dr. Julia Anne Maresca

Warga Negara : Amerika Serikat Jabatan : Associate Professor Institusi : University of Delaware No. SIP : 378SIPFRPSMIX2013

72.7 Ms. Céline Chantal Philippe Michiels

Warga Negara : Belgia Jabatan : Ph.D. Student Institusi : University of British Columbia No. SIP : 379SIPFRPSMIX2013

73. Collaborative Research Center for Emerging and Re-emerging Infectious Disease CRD – ERID”

Tujuan Penelitian : Mempelajari virus hepatitis B dan Hepatitis C pada penderita karier asimtomatik, hepatitis kronis, kanker hati dan karsinoma hepatoselular Bidang Penelitian : Mikrobiologi Daerah Penelitian : Jawa Timur Surabaya, DI. Yogjakarta, Kaltim TN.Samboja Lestari, Bali, Sulawesi Tenggara, Kalteng, Kalbar dan Kalsel Lama Penelitian : 12 dua belas bulan mulai 15 Oktober 2013 Mitra Kerja : Lembaga Penyakit Tropis, Universitas Airlangga Prof. Dr. H. Fasich, Apt. Absract The purposes of research are to determine the extent of infection on Hepatitis B virus HBV, hepatitis C virus IICV and hepatitis E virus HEV in Indonesia, and to clarify the characteristics of HBV, HCV and HEV in Indonesia. 126 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013 All the research activities on hepatitis viruses, such as hepatitis B virus HBV, hepatitis C virus HCV and hepatitis E virus HEV, will be conducted in Institute of Tropical Disease ITD, Airlangga University, in collaboration with Dr.Soetjipto, the head of the Viral Hepatitis research group at ITD, and his colleagues. A Japanese long-term researcher, Dr.Takako Utsumi, who stays at ITD to do research on viral hepatitis will be dispatched from Center for Infectious Diseases CID, Kobe Universiiy Graduate School of Medicine. The supervisors of the long- term researcher Dr.Yoshitake Hayashi and Dr.Hak Hotta andor their colleagues may be dispatched from CID for a short-term stay to join in the collaborative research activities ;it ITD. The following experiments on hepatitis viruses will be conducted. A. The entire genome of HBV obtained from asymptomatic carriers, and patients of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma will be sequenced to examine the possible correlation between the disease status and a particular mutation s of HBV B. The entire genome of HBV obtained from patients who responded either eiciently or poorly to lamivudine treatment will be sequenced to examine the possible correlation between the treatment responses and a particular mutation s of HBV C. Part of the HCV genome core, NS3. NS5A, NS5B. etc obtained from asymptomatic carriers, and patients of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma will be sequenced to examine the possible correlation between the disease status and a particular mutation s of HCV. D. Part of the HCV genome core, NS3, NS5A, NS5B, etc obtained from patients who responded either eiciently or poorly to the combination therapy with pegylated interferon and ribavirin will be sequenced to examine the possible correlation between the treatment responses and a particular mutation s of HCV. E. Part of the HCV genome core, NS3, NS5A, NS5B, etc obtained from HCV- infected patients will be sequenced to possibly identify naturally occurred genetic recombination of HCV F. Part of the HEV genome ORF2 etc obtained from HEV-infected patients and swine will be sequenced and compared with each other. 127 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013 G. Serum samples will be serologically HBsAg, anti-HCV, anti-HEV etc examined to determine the status of HBV, HCV and HEV infection with sequence results in given regions

73.1 Dr. Takako Utsumi

Warga Negara : Jepang Jabatan : Assistant Professor Institusi : International Center for Medical Research and Treatment ICMRT, Kobe University No. SIP : 355SIPFRPSMIX2013

74. Epidemiology of Plasmodium resistance to antimalarial drugs in Indonesia

Tujuan Penelitian : Mengetahui sejauh mana resistensi terhadap obat anti malaria telah tersebar pada parasit malaria di Indonesia Bidang Penelitian : Mikrobiologi Daerah Penelitian : DKI Jakarta Lama Penelitian : 6 enam bulan mulai 11 Oktober 2013 Mitra Kerja : LBM Eijkman dr. Din Syafruddin, Ph.D. Abstrak Malaria is a public health problem in many parts of the world, causing an estimated 300-500 million clinical cases of the disease and killing more than 1 million people annually. The molecular mechanisms underlying the parasite resistance have been extensively investigated and several polymorphisms in the genes of the Plasmodium spp. such as pfmdr1, pfcrt, pfcg2, dhfr and dhps havebeen associated with the phenomenon. Following our previous study in 10 diferent endemic areas see Syafruddin et al, 2003; Syafruddin et al, 2005, we are currently planning to explore the frequency distribution of the mutant alleles in the aforementioned genes in another 24 malaria endemic areas across the archipelago. 128 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013 Information regarding the frequency distribution of the alleles in a given area will be of particular importance to the establishment of proper malaria control strategy.Mutant alleles in the genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine have been well documented. Eforts to determine the frequency distribution of the alleles among the most common human plasmodia in Indonesia, P. falciparum and P. vivax would provide us invaluable information regarding the status of the parasite resistance in the area and that facilitate the use of proper antimalarial drugs to be used. The proposed project is planning to map the frequency distribution of the alleles in 24 malaria endemic areas in Indonesia. The project aims to determine how wide the distribution of antimalarial drugresistance has spread out among the malaria parasite in Indonesia by looking at the genetic make up of the malaria parasites in various diferent places in Indonesia. Several changes in the genes of the parasite, namely pfmdr1, pfcrt, pfcg2, dhfr and dhps have been implicated in the parasite resistance to chloroquine and itsderivatives such as piperaquine and amodiaquine. Frequency distribution of those genetic changes among the malaria parasite will indicate the current situation of antimalarial drug resistance in the area and will be important information for the establishment of antimalarial drug policy. The advent of molecular parasitology within the last few decades has enabled to diagnose genes associated with resistance to chloroquine and sulfadoxine- pyrimethamine using polymerase chain reaction PCR.

74.1 Ms. Myrte Charlot de Boer

Warga Negara : Belanda Jabatan : Student Institusi : University of Amsterdam No. SIP : 402SIPFRPSMX2013 129 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013

75. Molecular epidemiological and biological studies on human malaria parasites in Indonesia

Tujuan Penelitian : Melakukan studi epidemiologis molekuler pada parasit malaria yang menyerang manusia Bidang Penelitian : Mikrobiologi Daerah Penelitian : Jatim Surabaya Lama Penelitian : 12 dua belas bulan mulai 3 Juni 2013 Mitra Kerja : Lembaga Penyakit Tropis, Universitas Airlangga Indah S. Tantular, dr., Ph.D., Sp.ParK Abstrak The applicant has been working molecular epidemiological studies on human malaria parasites in Indonesia with Indonesian collaborators since 1995, and we have surveyed mainly at Eastern Indonesian islands, such as Lombok, Flores, Halmahera, Buru, Seram, Sumba, Sumbawa, Sulawesi Minahasa, Muna, Bangka and East Timor. From these surveys, we have found the existence of Plasmodium ovale with its new variant form from, and also the two new variant forms of P. malariae, all of which are distributing in SEA such as in Myanmar, Thailand, Vietnam, Cambodia and Laos. In the new project, the applicant would like to continue these molecular epidemiological studies on human malaria parasites in Indonesia as well as biological aspects of P. falciparum.

75.1 Prof. Fumihiko Kawamoto

Warga Negara : Jepang Jabatan : Professor Health Sciences Institusi : Oita University No. SIP : 181SIPFRPSMVI2013 130 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013

76. Molecular epidemiology of avian inluenza virus infection in Indonesia

Tujuan Penelitian : Meneliti epidemiologi molekuler dari infeksi virus lu burung pada unggas, hewan, dan manusia untuk mengontrol infeksi virus tersebut pada manusia Bidang Penelitian : Mikrobiologi Daerah Penelitian : Jatim Surabaya, Sidoarjo, Malang Lama Penelitian : 12 dua belas bulan mulai 3 Juni 2013 Mitra Kerja : Lembaga Penyakit Tropis Universitas Airlangga Prof. Dr. Nasronudin Abstract The Indonesia-Japan collaborative project to establish the “Collaborative Research Center for Emerging and Re-emerging Infectious Diseases” CRC-ERID has been approved and supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan, and now in progress since April 2007. CRC-ERID is established in Institute of Tropical Disease ITD, Airlangga University, and the collaborative research will continue until 31 st March 2015. The objectives of research are to advance molecular epidemiology of avian inluenza virus infection in birds, animals, and humans and to control human infection of the virus in Indonesia. All the research activities on avian inluenza will be conducted in Institute of Tropical Disease ITD, Airlangga University, in collaboration with Dr. Laksmi Wulandari, the head of the Avian Inluenza research group at ITD, Prof. Nasronudin, Director of ITD, and their colleagues. Prof. Kazufumi Shimizu, a Japanese long-term researcher who stays at ITD to carry out research on avian inluenza, will be dispatched from Center for Infectious Diseases CID, Kobe University Graduate School of Medicine. Also, Japanese collaborators of the long-term researcher Prof. Yoshitake Hayashi and Prof. Hak Hotta andor their colleagues will be dispatched from CfD, Kobe University for a short-term stay to join in the collaborative research activities at ITD. 131 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013 The following experiments on avian inluenza virus will be conducted. 1 The entire genome of some representative strains of highly pathogenic H5N1 avian inluenza virus obtained from chicken, wild birds and pigs as well as that of avirulent strains will be sequenced and compared with each other. 2 The hemagglutinin HA and the neuraminidase NA genes of the remaining strains obtained from chicken and pigs will be sequenced and compared. 3 The binding ainity of the above inluenza virus strains to the viral receptors of the human ct2-6 and the avian types a2-3 will be examined. The possible relationship between the receptor binding ainity and a mutations of the virus will be comparatively studied. 4 Heamagglutination inhibiting HI and neutralizing NT antibodies against H5N1 inluenzavirus as well as seasonal inluenza viruses H1N1 and H3N2, etc. in the sera of the above mentioned animals and humans patients, suspected cases and healthy people will be measured by HI and NT tests.

76.1 Prof. Kazufumi Shimizu

Warga Negara : Jepang Jabatan : Professor Microbiology Institusi : Kobe University No. SIP : 179SIPFRPSMVI2013

77. Raising artemisinin resistant strains of Plasmodium berghei in mice model

Tujuan Penelitian : Mengembangkan dan memilih mutan resisten artemisinin pada parasit malaria Plasmodium berghei Bidang Penelitian : Mikrobiologi Daerah Penelitian : DKI Jakarta LBM Eijkman Lama Penelitian : 7 tujuh bulan mulai 19 Februari 2013 Mitra Kerja : LBM Eijkman Dr. Josephine E. Siregar, Prof. Sangkot Marzuki 132 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013 Abstrak This project aims to raise and select artemisinin resistant mutants of the murine malaria parasite Plasmodium berghei at the Eijkman Institute of Molecular Biology EIBM in Jakarta in collaboration with Leiden University Medical Center. Selection of resistant strains is essential to unravel the mechanism of antimalarial action of artemisinin.By exerting repeated drug selection pressure on Plasmodium berghei in mice, artemisinin resistant strains of Plasmodium berghei are expected to appear and acquisition of resistance can be validated. Main objectives are to: 1 Select artemisinin resistant strains of Plasmodium berghei; 2 Compare the acquisition and the phenotype of resistance of diferent Plasmodium berghei isolates subjected to artemisinin selection pressure.

77.1 Ms. Jessica Paulina Roelands

Warga Negara : Belanda Jabatan : Student Institusi : Leiden University Medical Center No. SIP : 056SIPFRPSMII2013 133 Sekretariat Perizinan Penelitian Asing Kementerian Riset dan Teknologi DIREKTORI PENELITIAN ASING DI INDONESIA 2013

Bab 5: Bidang BOTANI PERTANIAN

Dalam bidang Botani dan Pertanian terdapat 15 project penelitian no. 78 sd 92.

78. Biogeography, ecology and informatics of Indonesian trees

Tujuan Penelitian : Mengembangkan informasi keberagaman khususnya di bidang biogeograik dan diversiikasi ekologi tumbuhan Indonesia Bidang Penelitian : Botani Daerah Penelitian : Papua Cagar Alam P. Waigeo Timur dan Cagar alam Tamrau Utara di Kab. Sorong, Sulut TN Bogani Nani Wartabone, Porv. NTT Flores Barat - Kab. Manggarai Barat dan Wai Dongkong, Prov. Maluku P.Yamdena- Tanimbar, Kab. Maluku Tenggara Barat Lama Penelitian : 8 delapan bulan mulai 10 April 2013 Mitra Kerja : Puslit Biologi LIPI Arief Hidayat, M.Si. Abstrak The Indonesian archipelago contains tree communities of outstanding biodiversity and endemism, and represents the most dynamic and potentially informative biogeographic experiment on earth. Forest trees also form the basis of the vital Indonesian timber industry. At the same time, much of the information there is about tree species is not available to most Indonesian and global researchers, and there is a great need for capacity building in Indonesian biodiversity informatics. In 2010, a joint team of US and Indonesian researchers received funding from theUS National Science Foundation for a three-year study of the biogeographic assemblyof tree communities across the archipelago, with development of associated biodiversityinformatics resources in Indonesia, and this Indonesian research permit proposal is forYear 3 activities outlined in the attached NSF document.