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72.6 Dr. Julia Anne Maresca
Warga Negara : Amerika Serikat
Jabatan : Associate Professor
Institusi : University of Delaware
No. SIP : 378SIPFRPSMIX2013
72.7 Ms. Céline Chantal Philippe Michiels
Warga Negara : Belgia
Jabatan : Ph.D. Student
Institusi : University of British Columbia
No. SIP : 379SIPFRPSMIX2013
73. Collaborative Research Center for Emerging and Re-emerging Infectious Disease CRD – ERID”
Tujuan Penelitian : Mempelajari virus hepatitis B dan Hepatitis C pada penderita karier asimtomatik, hepatitis kronis, kanker hati
dan karsinoma hepatoselular Bidang Penelitian
: Mikrobiologi Daerah Penelitian
: Jawa Timur Surabaya, DI. Yogjakarta, Kaltim TN.Samboja Lestari, Bali, Sulawesi Tenggara, Kalteng, Kalbar dan
Kalsel Lama Penelitian
: 12 dua belas bulan mulai 15 Oktober 2013 Mitra Kerja
: Lembaga Penyakit Tropis, Universitas Airlangga Prof. Dr. H. Fasich, Apt.
Absract
The purposes of research are to determine the extent of infection on Hepatitis B virus HBV, hepatitis C virus IICV and hepatitis E virus HEV in Indonesia, and to
clarify the characteristics of HBV, HCV and HEV in Indonesia.
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All the research activities on hepatitis viruses, such as hepatitis B virus HBV, hepatitis C virus HCV and hepatitis E virus HEV, will be conducted in Institute
of Tropical Disease ITD, Airlangga University, in collaboration with Dr.Soetjipto, the head of the Viral Hepatitis research group at ITD, and his colleagues.
A Japanese long-term researcher, Dr.Takako Utsumi, who stays at ITD to do research on viral hepatitis will be dispatched from Center for Infectious Diseases
CID, Kobe Universiiy Graduate School of Medicine. The supervisors of the long- term researcher Dr.Yoshitake Hayashi and Dr.Hak Hotta andor their colleagues
may be dispatched from CID for a short-term stay to join in the collaborative research activities ;it ITD.
The following experiments on hepatitis viruses will be conducted. A. The entire genome of HBV obtained from asymptomatic carriers, and
patients of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma will be sequenced to examine the possible correlation between the disease
status and a particular mutation s of HBV
B. The entire genome of HBV obtained from patients who responded either eiciently or poorly to lamivudine treatment will be sequenced to examine
the possible correlation between the treatment responses and a particular mutation s of HBV
C. Part of the HCV genome core, NS3. NS5A, NS5B. etc obtained from asymptomatic carriers, and patients of chronic hepatitis, liver cirrhosis
and hepatocellular carcinoma will be sequenced to examine the possible correlation between the disease status and a particular mutation s of HCV.
D. Part of the HCV genome core, NS3, NS5A, NS5B, etc obtained from patients who responded either eiciently or poorly to the combination therapy with
pegylated interferon and ribavirin will be sequenced to examine the possible correlation between the treatment responses and a particular mutation s of
HCV.
E. Part of the HCV genome core, NS3, NS5A, NS5B, etc obtained from HCV-
infected patients will be sequenced to possibly identify naturally occurred genetic recombination of HCV
F. Part of the HEV genome ORF2 etc obtained from HEV-infected patients and
swine will be sequenced and compared with each other.
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G. Serum samples will be serologically HBsAg, anti-HCV, anti-HEV etc examined
to determine the status of HBV, HCV and HEV infection with sequence results in given regions
73.1 Dr. Takako Utsumi
