B. Saran
1. Validasi contourplot superimposed dilakukan pada banyak titik agar dapat menggambarkan sifat fisik pada daerah optimum secara keseluruhan
2. Sebaiknya dilakukan replikasi pada saat pengujian aktivitas lotion minyak nilamm sehingga dapat diketahui signifikansi daya proteksi lotion minyak
nilam dengan kontrol positif terhadap nyamuk A. aegypti. 3. Lotion perlu diperbaiki dari segi ukuran droplet. Salah satu cara untuk
memperbaiki kestabilan ukuran droplet dengan penggunaan solid particle adsorption
, misal : bentonite, magnesium hidroksida, alumunium hidroksida, dan magnesium trisilikat.
67
DAFTAR PUSTAKA
Allen, L. V., 2014, Ansel’s Pharmaceuticals Dosage Forms and Drug Delivery
System, 10
th
ed., Lippincott Williams and Wilkins, Baltimore, pp.466, 788.
Ansel, H.C., 1989, Introduction to Pharmaceuticals Dosage Forms, Lea Febiger, Philadelphia, pp. 248-251.
Bolton, S., 1997, Pharmaceuticals Statistic Principal and Clinical Application, 3
rd
ed., Marcel Dekker, Inc., New York, pp. 308-337, 532-574. Bunrathep, S., Lockwood, G. B., Songsak, T., and Ruangrungsi, N., 2006,
Chemical Constituents from Leaves and Cell Cultures of Pogostemon cablin
and Use of Precursor Feeding to Improve Patchouli Alcohol Level, ScienceAsia, 32, 293-296.
Cazedey, E., Calvalho, F., Fiorentino, F., Gremiao, M., and Salgado, H., 2009, Corrositex, BCOP, and HET-CAM as alternative methods to animal
experimentation, Braz J Med Biol Res, 34 2, 1-23. Chakrapani, P., et al., 2013, Phytochemical, Pharmacological Importance of
Patchouli Pogostemon cablin Blanco Benth An Aromatic Medical Plant, Int. J. Pharm. Sci. Rev. Res., 21 2, 7-15.
Debboun, M., Frances, and S.P., Strickman, D., 2006, Insect Repellents : Principles, Methods, and Uses,
CRC Press, Florida, p.40. Degner, B.M., Cheryl C., Vicki S., Robert H., David J.M., 2014, Factors
Influencing the Freeze-Thaw Stability of Emulsion-Based Foods, Comprehensive Reviews in Food Science and Food Safety,
13 2, 98- 113.
Draganoiu, E., Rajabi Siahboomi, A,, and Tjawari S., Carbomer in Rowe, R.C., et al., Handbook of Pharmaceuticals Excipients,
6
th
ed., Pharmaceuticals Press, London, pp. 110-114.
Dung, N. X., Leclercq, P. A., Thai, T. H., and Moi, L. D., 1989, Chemical Composition of Patchouli Oil of Vietnam, J. Essent. Oil Res., 12, 99-
100. Eccleston, G.M., and Florence, A.T., 1985, Application of emulsion theory to
complex and real systems, International Journal of Cosmetic Science, 7 5, 195-212.
Felton, L.A., 2013, Remington: Essential of Pharmaceutics, Pharmaceutical Press, London, p.387.
Garg, A., Aggarwal, D., Garg, S., and Singla, A. K., 2002, Spreading of Semisolid Formulations, Pharmaceutical Technology, 26 9, 84-105.
Ginanjar, G., 2007, Demam Berdarah, Bentang Pustaka, Jakarta, pp. 19-23. Gokulakhrishnan, J., Kuppusamy, E., Shanmugam, D., and Kaliyamoorthi K.,
2013, Pupicidal and Repellent Activities of Pogostemon Cablin Essential oil Chemical Compound Against Medically Important Human Vector
Mosquitoes, Asian Pac. J. Trop. Dis., 31, 26-31.
Goskonda, SD., 2009, Triethanolamine, in Rowe, R.C., et al., Handbook of Pharmaceuticals Excipients,
6
th
ed., Pharmaceuticals Press, London, pp. 754-755.
Guan, L., Quan, LH., Xu, LZ., and Cong, PZ., 1994, Chemical Constituents of Pogostemon cablin Blanco Benth., Zhongguo Zhong Yao Za Zhi, 196,
355-6, 383. Guojon, Lv., Fumin W., Wangfeng C., and Xubin Z., 2014, Characterization of
the addition of lipophilic Span 80 to the Hydrophilic Tween 80- Stabilized Emulsions, Colloids and Surfaces A: Physicochemical and
Engineering Aspects, 447, 8-13.
Halley, S., 2009, Methylparaben Carbomer in Rowe, R.C., et al., Handbook of Pharmaceuticals Excipients,
6
th
ed., Pharmaceuticals Press, London, pp. 442-445.
Istianto, M., 2009, Pemanfaatan Minyak Atsiri, Alternatif Teknologi Pengendalian Organisme Pengganggu Tanaman Buah yang Ramah
Lingkungan, Balai Penelitian Tanaman Buah Tropika, Solok, p.35.
Jufri M., Anwar E., dan Utami P. m., 2006, Uji Stabilitas Sediaan MikroemulsiMenggunakan Hidrosilat Pati De 35-40 Sebagai Stabilizer,
Majalah Ilmu Kefarmasian, 31, 8-20. Kibbe. AH., 2009, Acacia Rowe, R.C., et al., Handbook of Pharmaceuticals
Excipients, 6
th
ed., Pharmaceuticals Press, London, pp. 1-3. Kurniawan, D.W., dan Sulaiman, T.N., 2009, Teknologi Sediaan Farmasi, Graha
Ilmu Yogyakarta, pp.97-99. Lieberman, H. A., Rieger, M. M, Banker, G. S., and Dekker, M., 1996,
Pharmaceutical Dosage Forms: Disperse Systems , Informa Healthcare,
London, pp.257-258. Lundstet, T., Seifert, E., Abrambo, L., Thelin, B., Nystrom, A., and Pettersen, J.,
et al., 1998, Experimental Design and Optimization, Chemometrics and
Intelligent Laboratory Systems, 42, 3-40.
Luukinen, B., Buhl, K., and Stone, D., 2008, DEET Technical Fact Sheet, National Pesticide Information Center, Oregon State University
Extension Services, pp. 1-9.
Mahanta, J.J., and Sarma T.C., 2007, Study on Weed Flora and Their Influence on Patchouli Pogostemon cablin Benth. Oil and Patchoulol, Journal of
Plant Science, 2:96-101.
Martin, A., Swarbick, J., Cammarata, A., 1993, Physical Pharmacy, 3
rd
ed., Lea Febiger, Philadelphia, pp. 522-537, 1077-1119.
Miyazawa, M., Okuno, Y., Nakamura, S., and Kosaka, H., 2000, Antimutagenic Activity of Flavonoids from Pogostemon Cablin, J. Agric. Food Chem.,
48, 642-647. Muzzafar, F., Singh, U. K., and Chauhan, L., 2013, Review on Microemulsion as
Futuristic Drug Delivery, Int J Pharm Pharm Sci, 53, 39-53. Nielloud, F., and Marti-Mestres, G., Eds. 2000, Pharmaceutical Emulsions and
Suspensions, Marcell Dekker, New York, pp. 20-22.
Ramya, H. G., Palanumuthu V., and Singla, R., 2103, An Introduction to Patchouli Pogostemon Cablin Benth.- A medicinal and Aromatic Plant:
It‟s Importance to Mankind, Agric. Eng. Int: CIGR Journal, 152, 243- 250.
Santoso, B.H., 1990, Bertanam Nilam, Kanisius, Yogyakarta, pp. 18-23. Sheikh, K.A., Baie, S. HJ., Khan, M. G., 2005, Haruan Chana Striatus
Incorporated Palm-Oil Creams: Formulation and Stability Studies, Pakistan Journal of Pharmaceutical Sciences,
181, 1-5. Soedarto, 2011, Buku Ajar Parasitologi Kedokteran, Sagung Seto, Jakarta, pp.
269, 270. Subdirektorat Arbovirus, 2009, Database Kasus DBD pada Tahun 1968-2009,
Ditjen PPPL, Kementrian Kesehatan RI. Thanasukarn P., Pongaswatmanit R., and D.J. McClements, 2004, Influence of
Emulsifier Type on Freeze Thaw Stability of Hydrogenated Palm Oil-in- Water Emulsions, Foodhyd.
Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., and Apiwathnasorn, C., 2005, Comparative Repellency of 38 Oils Against Mosquito, Phytother. Res.,
194, 303-309. Troy, D.B., and Beringer, P., 2006, Remington : The Science and Practice of
Pharmacy, 21
st
ed., Lippincott Williams and Wilkins, Baltimore, pp. 246, 326, 759, 772.
Unvala, HM., Cetyl Alcohol in Rowe, R.C., et al., Handbook of Pharmaceuticals Excipients,
6
th
ed., Pharmaceuticals Press, London, pp. 154-156.
Weller, PJ., Propylene Glicol in Rowe, R.C., et al., Handbook of Pharmaceuticals Excipients
6
th
ed., Pharmaceuticals Press London, pp. 592-593. Zhang, D., 2009, Polyoxyethylene Sorbitan Fatty Acid Esters in Rowe, R.C., et
al., Handbook of Pharmaceuticals Excipients, 6
th
ed., Pharmaceuticals Press, London, pp. 554-556.
Zhang, D., 2009, Sorbitan Esters in Rowe, R.C., et al., Handbook of Pharmaceuticals Excipients,
6
th
ed., Pharmaceuticals Press, London, pp. 554-556.
Zwiebel. L.J., Takken, W., 2004, Olfactory Regulation of Mosquito-Host Interaction, Insect Biochem Mol Biol, 347: 645
–652.
71
LAMPIRAN
Lampiran 1. Surat Keterangan Pembelian Minyak Nilam dari Balitro
Lampiran 2. Sertifikat Pengujian Minyak Nilam
Lampiran 3. Perhitungan nilai HLB :
HLB Span 80 = 4.3
HLB Tween 80 = 15
Nilai HLB Formula A
Nilai HLB Formula B
Nilai HLB Formula AB
Nilai HLB Formula I
Lampiran 4. Organoleptis Lotion Minyak Nilam
A. Penyimpanan 1 Bulan
Formula Pengamatan
Lama Penyimpanan 48
jam 1
minggu 2
minggu 3
minggu 4
minggu A
Warna Putih
kekunin gan
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan Putih
kekunin gan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Tekstur Kental
Kental Kental
Kental Kental
Homogenitas ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
B Warna
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Tekstur Kental
Kental Kental
Kental Kental
Homogenitas ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
AB Warna
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Tekstur Kental
Kental Kental
Kental Kental
Homogenitas ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
1 Warna
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan Putih
kekunin gan
Putih kekunin
gan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Tekstur Kental
Kental Kental
Cair Cair
Homogenitas ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
Formula A Formula B
Formula AB Formula I
Lotion minyak nilam sebelum penyimpanan 1 bulan
Formula A Formula B
Formula AB Formula I
Lotion Minyak Nilam pada minggu ke 4
B. Freeze Thaw Cycle
Form. Pengamatan
Siklus ke 1
2 3
4 5
A Warna
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam
Tekstur Kental
Kental Kental
Kental Kental
Kental Homogenitas
˅ ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
X B
Warna Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam
Tekstur Kental
Kental Kental
Kental Kental
Kental Homogenitas
˅ ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
X AB
Warna Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam
Tekstur Kental
Kental Cair
Cair Cair
Cair Homogenitas
˅ ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
X 1
Warna Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan Putih
kekuni ngan
Putih kekuni
ngan
Bau Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam Khas
minyak nilam
Khas minyak
nilam
Tekstur Kental
Kental Cair
Cair Cair
Cair Homogenitas
˅ ˅
˅ ˅
˅ ˅
Mikroba X
X X
X X
X