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Methods Optimization of the Acid Catalyst Concentration for Synthesis of Anti‐Cancer Agent Gamavuton‐0 by Using Mathematical and Statistical Software

2 properties, they did not meet the standard requirement. So, they should be optimized. The results of the formula optimization were formula and formula . Table is a reference formula that had been researched by idayati . The formula contained extracts, lactose, citric acid, tartaric acid, potassium bicarbonate, magnesium stearate, aspartame, and PVP. n this study, there are some differences and changes of the formula, namely adding additives, such as sodium bicarbonate and mannitol. Sodium bicarbonate is a frequently‐used alkali base source, while mannitol provides a cooling sensation in the mouth Rowe et al., . Table . Formulation of effervescent tablet ngredients Functions Formula Purple mangosteen and apple peel extracts Active ingredient Lactose Filler . Aspartame Sweetener . Citric acid Acid source Granule extra Crusher . Sodium bicarbonate Base source Granule extra Crusher . Magnesium stearate Lubricant . Mannitol Sweetener . PVP Binder . 3.4. Effervescent Tablet Preparation Effervescent granules obtained were pressed with a single punch tablet machine. Both tablets and all tablet tests were done with relative humidity of ‐ . The weight of each tablet that will be created was milligrams.

4. Result and Discussion

4.1. Extract preparation The extraction method used in this study was maceration. The solvent used in this maceration was ethanol. The yield of the resulting purple mangosteen peel extract was . , while apple was . . t showed that there were polar compounds in the peel of purple mangosteen Garcinia mangostana L and apple Pyrus mallus L . t means that these compounds are soluble in ethanol. The extraction used ethanol because desired thickened extracts had polar properties. The terms of ingredients used in this study were water soluble, so polar thickened extracts will be easily dissolved. 4.2. Optimization and Scale Up The effervescent tablet optimization used in this study was a formula design as presented on the table . This optimization was done in the preparation and formula of the effervescent tablets. Unfortunately, the physical parameters of the formula were less good, so the formula needs to be optimized.

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